《生命科学》 2022, 34(5): 565-572

糖原合酶激酶-3β：炎症性肠病的潜在重要调节靶点

马成全 , 顿耀艳 , 刘　雨 , 李艳丽 , 熊正国 , 张长城 , 郭煜晖^*

三峡大学医学院，三峡大学国家中医药管理局中药药理科研三级实验室，宜昌 443002

摘　要：

炎症性肠病(inflammatory bowel disease, IBD) 是一种慢性非特异性肠道炎症性疾病，主要包括溃疡性结肠炎和克罗恩病，具有难治愈、易复发、癌变率高和易引起肠道反复损伤等特点。据报道IBD 与遗传、环境及自身免疫等因素有关，但其具体发病机制仍不明确。近年来研究发现，糖原合酶激酶-3β(glycogen synthase kinase-3β, GSK-3β) 参与了炎症反应的多条调控途径，其激活状态可增强炎症反应调控相关信号，促进肠道炎症反应。该文从细胞因子调控、NF-κB 信号通路、内质网应激等多个方面综述了GSK-3β 在IBD 发病机制中的潜在作用，以期为IBD 的治疗和药物研发提供新思路和有益线索。

通讯作者：郭煜晖 , Email:381977017@qq.com

Glycogen synthase kinase-3β: a potential important regulatory target in inflammatory bowel disease

MA Cheng-Quan , DUN Yao-Yan , LIU Yu , LI Yan-Li , XIONG Zheng-Guo , ZHANG Chang-Cheng , GUO Yu-Hui^*

Third-grade Pharmacological Laboratory on Traditional Chinese Medicine, State Administration of Traditional Chinese Medicine, Medical College, China Three Gorges University, Yichang 443002, China

Abstract:

Inflammatory bowel disease (IBD) is a chronic non-specific inflammatory disorder of the intestine, mainly including ulcerative colitis and Crohn's disease, which is difficult to cure, prone to recurrence, of high cancer rate, and easily causes repeated intestinal damage. It has been reported that IBD is associated with genetic, environmental and autoimmune factors, but the specific pathogenesis of IBD is still unclear. In recent years, glycogen synthase kinase-3β (GSK-3β) has been found to be involved in multiple regulatory pathways of inflammatory reaction, which can enhance the signal related to inflammatory reaction and promote intestinal inflammatory reaction upon activation. In this review, we summarize the potential role of GSK-3β in the pathogenesis of IBD from the aspects of cytokine regulation, NF-κB signaling pathway, endoplasmic reticulum stress and so on, to provide new ideas and useful clues for the treatment and drug development of IBD.

Communication Author：GUO Yu-Hui , Email:381977017@qq.com