《生命科学》 2022, 34(4): 477-483

循环肿瘤细胞在乳腺癌诊疗中的应用

马新寓¹ , 郑亚赏¹ , 周雪冰¹ , 杨春宇¹ , 任香善^2,3,*

¹延边大学医学院，延吉 133002 ²延边大学肿瘤研究中心，延吉 133002 ³国家民委重点实验室，吉林省科技厅重点实验室，延吉 133002

摘　要：

乳腺癌作为在女性中患病率最高的肿瘤，其对患者造成的生命威胁不容忽视。乳腺癌复发率高、转移性强是导致患者死亡的重要因素，而循环肿瘤细胞是启动远处转移的重要环节。循环肿瘤细胞(circulating tumor cells, CTCs) 作为液体活检技术的重要检测对象，现已成为众多乳腺外科学者研究的热点。作为一种无创、可重复且具有代表性的液体活检技术，循环肿瘤细胞检测在诊断病情、指导治疗以及判断乳腺癌患者预后情况等方面具有重要价值。该文主要针对循环肿瘤细胞在乳腺癌诊断及临床治疗中的作用展开阐述，以期为临床上乳腺癌的诊疗提供新方向。

通讯作者：任香善 , Email:renxsh@ybu.edu.cn

Application of circulating tumor cells in diagnosis and treatment of breast cancer

MA Xin-Yu¹ , ZHENG Ya-Shang¹ , ZHOU Xue-Bing¹ , YANG Chun-Yu¹ , REN Xiang-Shan^2,3,*

¹College of Medicine, Yanbian University, Yanji 133002, China ²Cancer Research Center of Yanbian University, Yanji 133002, China ³State Key Laboratory Of Civil Affairs/Key Laboratory of Science and Technology Department of Jilin Province, Yanji 133002, China

Abstract:

Breast cancer is the most prevalent tumor in women, and its threat to life can not be ignored. The high recurrence rate and strong metastasis of breast cancer are important factors leading to death. Circulating tumor cells (CTCs) are important steps to initiate distant metastasis. As an important detection object of liquid biopsy technology, circulating tumor cells have become a research hotspot of many breast surgeons. As a non-invasive, repeatable and representative liquid biopsy technology, circulating tumor cell detection is of great value in diagnosing the disease, guiding treatment and judging the prognosis of breast cancer patients. This article mainly focuses on the role of circulating tumor cells in the diagnosis and clinical treatment of breast cancer, so as to provide a new direction for clinical diagnosis and treatment of breast cancer.

Communication Author：REN Xiang-Shan , Email:renxsh@ybu.edu.cn