《生命科学》 2022, 34(4): 468-476

纳米抗体在癌症治疗中的研究进展

周慧慧^1,2,3 , 陈　曲^1,3,4 , 杨晓梅^1,3,* , 卢小玲^1,3,4,*

¹广西医科大学广西纳米抗体研究重点实验室，南宁 530021 ²广西医科大学再生医学与医用生物资源开发应用协同创 新中心，南宁 530021 ³广西纳米抗体国际联合研究中心，南宁 530021 ⁴广西医科大学口腔医学院，南宁 530021

摘　要：

纳米抗体是一种单域抗体，具有体积小(~15 kDa)、稳定性好、易于加工和修饰、循环半衰期短、组织穿透性高、特异性和亲和力高等优点。因此，纳米抗体在疾病治疗研究中极具吸引力。癌症是严重危害人类健康的一类疾病，其治疗方法多种多样，其中靶向治疗逐渐成为癌症治疗的重要疗法之一。该文回顾并展望了纳米抗体结合不同技术平台在癌症靶向治疗领域的应用。

通讯作者：杨晓梅 , Email:260718428@qq.com 卢小玲 , Email:luxiaoling@gxmu.edu.cn

Recent advances in nanobody based therapeutics in cancer

ZHOU Hui-Hui^1,2,3 , CHEN Qu^1,3,4 , YANG Xiao-Mei^1,3,* , LU Xiao-Ling^1,3,4,*

¹Key Laboratory for Nanobody Research of Guangxi, Guangxi Medical University, Nanning 530021, China ²Collaborative Innovation Centre of Regenerative Medicine and Medical BioResource Development and Application, Guangxi Medical University, Nanning 530021, China ³International Nanobody Research Center of Guangxi, Nanning 530021, China ⁴College of Stomatology, Guangxi Medical University, Nanning 530021, China

Abstract:

Nanobodies are single-domain antibodies, with many properties such as small size (~15 kDa), stability, ease of labeling and engineering for diverse formats, short circulatory half-life, high tissue penetration, high specificity, and high affinity. Therefore, it is very attractive in the research of disease treatment. Cancer is a kind of disease which seriously endangers human health. There are many treatments for cancer, among which targeted therapy has become one of the most important treatments in cancer treatment. This article reviews and prospects applications of nanobodies combined with different technology platforms in the field of cancer targeted therapy.

Communication Author：YANG Xiao-Mei , Email:260718428@qq.com LU Xiao-Ling , Email:luxiaoling@gxmu.edu.cn