《生命科学》 2022, 34(4): 420-426

间充质干细胞治疗脓毒症的研究进展

邓　捷^1,2 , 黄启林³ , 黄尚卿⁴ , 陈　重⁵ , 李　薇⁶ , 史惠卿¹ , 孙红玉^2,6,*

¹西部战区总医院临床药学科，成都 610083 ²西南交通大学医学院，成都 610031 ³天津医科大学，天津 300070 ⁴西部战区总医院普通外科，成都 610083 ⁵西部战区 总医院超声科，成都 610083 ⁶西部战区总医院基础医学实验室，成都 610083

摘　要：

脓毒症是一种严重的、威胁生命的炎症反应综合征，目前仍以对症支持治疗为主。因此，亟需寻找一种新的治疗策略以改善脓毒症患者预后。间充质干细胞(mesenchymal stem cells, MSCs) 因其独特的生物学特性，备受生命科学及医学领域研究者青睐。近年来，多项研究表明MSCs 可通过调节免疫状态、平衡炎症反应、降低细菌负荷、改善器官功能等途径，进而提高脓毒症机体的生存率，这表明MSCs 有望成为脓毒症治疗新策略。本文就MSCs 在脓毒症临床前与临床研究中的最新进展作一综述。

通讯作者：孙红玉 , Email:shongyu2008@163.com

Research progress of mesenchymal stem cell therapy for sepsis

DENG Jie^1,2 , HUANG Qi-Lin³ , HUANG Shang-Qing⁴ , CHEN Zhong⁵ , LI Wei⁶ , SHI Hui-Qing¹ , SUN Hong-Yu^2,6,*

¹Department of Clinical Pharmacy, The General Hospital of Western Theater Command of PLA, Chengdu 610083, China ²School of Medicine, Southwest Jiaotong University, Chengdu 610031, China ³Tianjin Medical University, Tianjing 300070, China ⁴Department of General Surgery, The General Hospital of Western Theater Command of PLA, Chengdu 610083, China ⁵Department of Ultrasound, The General Hospital of Western Theater Command of PLA, Chengdu 610083, China ⁶Laboratory of Basic Medicine, The General Hospital of Western Theater Command of PLA, Chengdu 610083, China

Abstract:

Sepsis is a serious and life-threatening inflammatory response syndrome, which is still treated mainly by symptomatic support. Therefore, there is an urgent need to find a new treatment strategy to improve the prognosis of patients with sepsis. Mesenchymal stem cells (MSCs) are favored by researchers in the field of life science and medicine because of their unique biological characteristics. In recent years, many studies have shown that MSCs can improve the survival rate of sepsis by regulating immune state, balancing inflammatory response, reducing bacterial load and improving organ function, which indicates that MSCs is expected to be a new strategy for the treatment of sepsis. This article reviews the latest progress of MSCs in preclinical and clinical study of sepsis.

Communication Author：SUN Hong-Yu , Email:shongyu2008@163.com