《生命科学》 2022, 34(4): 401-408
细胞焦亡在骨关节炎中的作用机制研究进展
摘 要：
骨关节炎是一种以软骨降解、滑膜炎症和软骨下骨重塑为特征的慢性炎症性关节疾病。骨关节炎的发生可能由遗传、环境、代谢和机械应力等多因素共同影响，发病机制复杂。最近研究发现，一种程序性炎性细胞死亡形式—— 细胞焦亡可能在这种慢性炎症疾病中发挥重要作用。滑膜细胞焦亡和软骨细胞焦亡在骨关节炎发生发展中的作用被陆续报道，NF-κB、P2X7、Nrf2 和HIF-1α 等多个重要细胞因子可能在NLRP 炎症小体介导的骨关节炎细胞焦亡过程中发挥重要作用。然而，目前骨关节炎相关的焦亡研究尚处于初步阶段，其具体调控机制尚不完全清晰。因此，该文通过查阅近年来有关骨关节炎滑膜和软骨细胞焦亡的相关研究，总结细胞焦亡过程中可能存在的关键靶点分子，为骨关节炎治疗靶点和发病机制的研究提供科学参考和依据。
通讯作者：倪国新 , Email:niguoxin@bsu.edu.cn
Abstract:
Osteoarthritis (OA) is a chronic inflammatory degenerative joint disease characterized by cartilage degradation, synovial inflammation and subchondral bone remodeling. The occurrence of OA may be affected by multiple factors such as genetics, environment, metabolism and mechanical stress, and its pathogenesis is complicated. Recent studies have found that a form of programmed inflammatory cell death, pyroptosis, may play an important role in OA. The role of synoviocyte pyroptosis and chondrocyte pyroptosis in the occurrence and development of OA has been reported. Many key cytokines such as NF-κB, P2X7, Nrf2 and HIF-1α may play an important role in the pyroptosis of OA mediated by NLRP inflammasome. However, the research of OA-related pyroptosis is still in the preliminary stage, and its potential mechanism is not yet fully understood at present. Therefore, we reviewed the relevant research on synovial and chondrocyte pyroptosis in OA in recent years and summarized the key targets that may exist in the process of pyroptosis, which may provide reference and basis for the research of OA treatment and pathogenesis.
Communication Author：NI Guo-Xin , Email:niguoxin@bsu.edu.cn
