《生命科学》 2022, 34(4): 385-391

糖脂代谢参与NLRP3炎症小体活化的研究进展

张　坦^1,2,* , 王　茹^1,2 , 丁树哲³

¹上海体育学院运动科学学院，上海 200438 ²上海市运动与代谢健康前沿科学研究基地， 上海 200438 ³华东师范大学青少年健康评价与运动干预教育部重点实验室，上海 200241

摘　要：

长期以来的研究认为慢性炎症与代谢性疾病的发生发展紧密相关，但二者之间的关系并不很明确。近年来研究发现，核苷酸结合寡聚化结构域样受体蛋白3 (nucleotide-binding oligomerization domain-like receptor protein 3, NLRP3) 不仅是先天性免疫系统的模式识别受体(pattern recognition receptors, PRRs) 之一，同时也是代谢紊乱的一种感应器。研究表明，糖脂代谢在NLRP3 炎症小体活化过程中具有重要调控作用，其中糖有氧氧化、糖酵解、磷酸戊糖途径以及脂肪酸合成分解、脂类合成产物和代谢物及其衍生物和类脂等均参与调控NLRP3 炎症小体活化。基于此，该文将对糖脂代谢在活化NLRP3 炎症小体中的作用进行综述，旨在为炎症相关疾病，尤其是代谢性疾病的防治提供理论依据。

通讯作者：张　坦 , Email:zhangtan@sus.edu.cn

Research progress on the regulation of NLRP3 inflammasome activation by glucose and lipid metabolism

ZHANG Tan^1,2,* , WANG Ru^1,2 , DING Shu-Zhe³

¹School of Kinesiology, Shanghai University of Sport, Shanghai 200438, China ²Shanghai Frontiers Science Research Base of Exercise and Metabolic Health, Shanghai 200438, China ³Key Laboratory of Adolescent Health Assessment and Exercise Intervention, Ministry of Education, East China Normal University, Shanghai 200241, China

Abstract:

It has been believed that chronic inflammation is closely related to the occurrence and development of metabolic diseases for a long time. However, the relationship between these two events is not completely clear. Recent studies have shown that nucleotide-binding oligomerization domain-like receptor protein 3 (NLRP3) is not only one of the pattern recognition receptors (PRRs) of the innate immune system, but also a sensor for metabolic disorder. It is well-established that glucose and lipid metabolism play vital roles in NLRP3 inflammasome activation. Especially, aerobic oxidation, glycolysis, pentose phosphate pathway, lipid synthesis, lipid oxidation, lipid metabolites, lipid derivates and lipoid are all involved in NLRP3 inflammasome activation. Therefore, this paper summarizes the role of glucose and lipid metabolism in NLRP3 inflammasome activation, hoping to provide theoretical evidence for preventing and treating inflammatory-associated diseases, especially the metabolic diseases.

Communication Author：ZHANG Tan , Email:zhangtan@sus.edu.cn