《生命科学》 2022, 34(4): 376-384

限时进食与代谢综合征的研究进展

张　慧 , 宋明明 , 张雯翔 , 陈思禹 , 刘　畅^*

(中国药科大学生命科学与技术学院，南京 211198

摘　要：

代谢综合征(metabolic syndrome, MS) 是全球关注的公共健康问题之一，其高发病率和高死亡率给各个国家带来了巨大的社会经济损失。研究发现，机体生物时钟紊乱是导致MS 发生的关键因素之一。机体生物时钟来自于内源性生物时钟与外部环境周期性变化的相互作用，它通过调控基因表达、激素释放、体温、活动模式、能量消耗等协调多种代谢过程。在众多外界环境授时因子中，食物信号被认为是一个重要的外周生物时钟系统重设因子，并深度影响代谢进程的节律性。限时进食(time-restricted feeding, TRF) 作为一种新的饮食干预策略，已成为当前研究的热点。它主要通过驱动时钟基因和营养感知通路的节律性振荡来预防和控制MS。该文将从时间生物学的角度讨论TRF 对MS 的影响并对其进行展望。

通讯作者：刘　畅 , Email:changliu@cpu.edu.cn

Research progress on time-restricted feeding and metabolic syndrome

ZHANG Hui , SONG Ming-Ming , ZHANG Wen-Xiang , CHEN Si-Yu , LIU Chang^*

School of Life Science and Technology, China Pharmaceutical University, Nanjing 211198, China

Abstract:

Metabolic syndrome (MS) is one of the major public health problems of global concern. Its high morbidity and mortality cause significant socio-economic loss in various countries. Of note, circadian disruption has been documented to be one of the risk factors for MS. Circadian clock emerges from interactions between endogenous circadian clocks and periodic changes of external environment. It coordinates a variety of metabolic processes by regulating gene expression, hormonal secretion, body temperature, activity mode, and energy expenditure. Among external Zeitgebers, food is known to be an important factor to reset the peripheral circadian system and affect the metabolic rhythmicity. Recently, time-restricted feeding (TRF), as a new dietary intervention strategy, has become the focus of current research. TRF orchestrates the rhythmicity of both circadian clock genes and nutrition-sensing pathways to prevent and improve MS. In this paper, the impact of TRF on MS from a chronobiological sight is reviewed and the future perspective in the clinic is discussed.

Communication Author：LIU Chang , Email:changliu@cpu.edu.cn