《生命科学》 2022, 34(3): 324-331

运动介导microRNAs改善慢性炎症及骨骼肌胰岛素抵抗的研究进展

李　楠¹ , 史海燕¹ , 周　越^1,2,*

¹北京体育大学运动人体科学学院，北京 100084 ²北京体育大学运动与体质健康教育部重点实验室，北京 100084

摘　要：

慢性炎症是引发骨骼肌胰岛素抵抗的主要原因，而运动是调节骨骼肌胰岛素抵抗及维持全身葡萄糖稳态的有效手段之一。microRNAs (miRNAs) 作为运动过程中机体发生变化的潜在生物标志物，其表达不仅参与调节骨骼肌增殖、分化等重要过程，而且与骨骼肌葡萄糖摄取及胰岛素抵抗发生发展也密切相关。但运动如何调控骨骼肌慢性炎症和胰岛素抵抗，以及miRNAs 在其中的调控机制尚不明确。该文梳理了近年来国内外有关运动调节miRNAs 表达改善慢性炎症，以及运动改善胰岛素抵抗的研究进展，为进一步揭示运动防治糖尿病等慢性疾病的机制提供新的研究思路。

通讯作者：周　越 , Email:zhouy@bsu.edu.cn

Research progress on the role of microRNAs in exercise improving chronic inflammation and skeletal muscle insulin resistance

LI Nan¹ , SHI Hai-Yan¹ , ZHOU Yue^1,2,*

¹School of Kinesiology, Beijing Sport University, Beijing 100084, China ²Key Laboratory of Physical Fitness and Exercise, Ministry of Education, Beijing Sport University, Beijing 100084, China

Abstract:

Chronic inflammation of skeletal muscle is the main cause of insulin resistance, while exercise is one of the effective means to regulate chronic inflammation and insulin resistance. Recent studies showed that microRNAs (miRNAs) can be used as potential biomarkers for adaptive changes in response to exercise. Meanwhile, miRNAs are important regulators of the proliferation and differentiation of skeletal muscle cells, and the regulation of expression levels is strongly associated with insulin resistance in skeletal muscle. However, it is not clear if exercise regulates inflammation in skeletal muscle by epigenetic mechanisms and how the miRNAs are involved in regulating inflammation and insulin resistance. Here, this review focuses on the recent progress in exercise that improves chronic inflammation and insulin resistance through miRNAs providing a scientific basis for exercise for the prevention and treatment of chronic diseases.

Communication Author：ZHOU Yue , Email:zhouy@bsu.edu.cn