《生命科学》 2022, 34(3): 302-313

Asprosin在肥胖和糖尿病中的作用及其与运动的关系

杨　旸^1,2 , 马　铁³ , 曹师承⁴ , 吕红艳⁵ , 衣雪洁^1,2,*

¹上海体育学院运动科学学院，上海 200438 ²沈阳体育学院运动与健康研究中心， 沈阳 110115 ³沈阳体育学院运动人体科学学院，沈阳 110115 ⁴中国医科大学公共基础 学院运动医学教研室，沈阳 110122 ⁵辽宁师范大学体育学院，大连 116029

摘　要：

白脂素(Asprosin, ASP) 是新发现的脂肪因子，在体内广泛表达，特别是在白色脂肪和肝脏中呈现高表达。研究发现，ASP 在调节糖代谢、促进食欲、增加炎症和胰岛素抵抗、降低自噬和氧化应激等过程中均发挥重要作用，且与肥胖和糖尿病的病理生理过程关系密切。此外，ASP 还参与了运动应答反应。该文梳理国内外相关文献，综述了ASP 的生物学特征、组织分布、生物学功能、在肥胖和糖尿病中的作用及其与运动的关系，旨在为研究相关疾病的治疗靶点提供新思路。

通讯作者：衣雪洁 , Email:Yixuejie8387@163.com

Advances in the study of Asprosin in obesity and diabetes and in response to exercise

YANG Yang^1,2 , MA Tie³ , CAO Shi-Cheng⁴ , LYU Hong-Yan⁵ , YI Xue-Jie^1,2,*

¹School of Kinesiology, Shanghai University of Sport, Shanghai 200438, China ²Exercise and Health Research Center, Shenyang Sport University, Shenyang 110115, China ³ollege of Kinesiology, Shenyang Sport University, Shenyang 110115, China ⁴Department of Sports Medicine, School of Fundamental Sciences, China Medical University, Shenyang 110122, China ⁵School of Physical Education, Liaoning Normal University, Dalian 116029, China

Abstract:

Asprosin (ASP) is a recently discovered adipocytokine, which is widely expressed in the body, especially in the white adipose tissue and liver. ASP plays an important biological role in regulating glucose and lipid metabolism, promoting appetite, increasing inflammation and insulin resistance, reducing autophagy and oxidative stress, and is closely related to the pathophysiological process of obesity and diabetes. In addition, the regulation of ASP also participated in the motor response. This review summarized the biological characteristics, tissue distribution and biological function of ASP, its role in obesity and diabetes, and the relationship between ASP and exercise, aiming to provide new ideas for researching the therapeutic targets for related diseases.

Communication Author：YI Xue-Jie , Email:Yixuejie8387@163.com