《生命科学》 2022, 34(3): 268-274

GPM6A在突触发育及相关神经精神疾病中的研究进展

董　博^1,2 , 武胜昔¹ , 王文挺¹ , 薛　茜^1,*

¹空军军医大学基础医学院神经生物学教研室，西安 710032 ²空军军医大学基础医学院学员队，西安 710032

摘　要：

突触发育、形成和可塑性异常被认为是神经精神疾病神经元功能改变的基础。糖蛋白M6A(glycoprotein M6a, GPM6A) 是一种在中枢神经系统神经元上表达的细胞表面跨膜蛋白。该文综述了GPM6A在神经元发育和突触形成中的作用，以及与各种神经精神疾病之间的关系。深入了解GPM6A 的分子功能有助于为相关神经精神疾病提供一个新的诊断和治疗靶点。

通讯作者：薛　茜 , Email:xueqianj@fmmu.edu.cn

Research progress of GPM6A in synaptic development and related neuropsychiatric disorders

DONG Bo^1,2 , WU Sheng-Xi¹ , WANG Wen-Ting¹ , XUE Qian^1,*

¹Department of Neurobiology, School of Basic Medicine, Fourth Military Medical University, Xi’an 710032, China ²Cadet Brigade, School of Basic Medicine, Fourth Military Medical University, Xi’an 710032, China

Abstract:

Dysregulated synaptic development, forming, and plasticity have been identified as the basis of neuronal dysfunction in neuropsychiatric disorders. Glycoprotein M6A (GPM6A) is a transmembrane protein on the surface of neurons in the central nervous system. This article reviews the vital roles of GPM6A in neuron development and synapse forming, and the relationship between GPM6A and neuropsychiatric disorders. Understanding the molecular function of GPM6A provides a new target for the diagnosis and treatment of related neuropsychiatric disorders.

Communication Author：XUE Qian , Email:xueqianj@fmmu.edu.cn