《生命科学》 2022, 34(3): 243-253

m6A甲基化修饰在胶质瘤中的研究进展

刘学润¹ , 曹　颖¹ , 汪应龙² , 王　瑞¹ , 张祎年^3,4,*

¹兰州大学第一临床医学院，兰州 730000 ²中南大学湘雅医学院，长沙 410000 ³兰州大学第二医院神经外科，兰州 730000 ⁴兰州大学神经病学研究所，兰州 730000

摘　要：

胶质瘤是中枢神经系统最常见的原发恶性肿瘤，预后较差，部分高级别胶质瘤即使采用手术联合放化疗的高强度治疗措施，效果也不理想。N6- 甲基腺嘌呤(N6-methyladenosine, m6A) 是真核生物信使RNA (messenger RNA, mRNA) 中最丰富的转录后RNA 修饰形式，在mRNA 剪接、翻译、运输、降解等过程中发挥关键作用。从肿瘤生物发生的角度探讨肿瘤的起源和发展机制一直是胶质瘤领域的研究热点。研究表明，m6A 甲基化修饰通过多种机制在胶质瘤中发挥关键作用，为胶质瘤的早期诊断和靶向治疗提供了更多的可能性。该文就m6A 甲基化修饰与神经胶质瘤的关系进行综述，为胶质瘤的早期诊断、组织学分级、靶向治疗及预后评估等方面的研究提供新的见解。

通讯作者：张祎年 , Email:ery_zhangyn@lzu.edu.cn

Research progress of m6A methylation modification in glioma

LIU Xue-Run¹ , CAO Ying¹ , WANG Ying-Long² , WANG Rui¹ , ZHANG Yi-Nian^3,4,*

¹The First School of Clinical Medicine, Lanzhou University, Lanzhou 730000, China ²Xiangya School of Medicine, Central South University, Changsha 410000, China ³Department of Neurosurgery, Lanzhou University Second Hospital, Lanzhou 730000, China ⁴Institute of Neurology, Lanzhou University, Lanzhou 730000, China

Abstract:

Glioma is the most common primary malignant tumor in the central nervous system and has a poor prognosis. Some high-grade gliomas have unsatisfactory therapeutic effects even though surgery is combined with radiotherapy. N6-methyladenosine (m6A) modification is the most abundant form of post-transcriptional RNA modification in eukaryotic messenger RNA (mRNA) and plays a key role in mRNA splicing, translation, transport and degradation. Exploring the mechanism of tumor origin and development from the perspective of tumor biogenesis has been a hot research topic in the field of glioma. Studies have shown that m6A methylation modification plays a key role in glioma through multiple mechanisms, providing more possibilities for early diagnosis and targeted treatment of glioma. In this review, the relationship between m6A methylation modifications and glioma is discussed, providing new insights into the early diagnosis, histological grading, targeted therapy and prognostic assessment of glioma.

Communication Author：ZHANG Yi-Nian , Email:ery_zhangyn@lzu.edu.cn