《生命科学》 2022, 34(2): 220-227

微生物合成黄酮类化合物研究进展

杨文博 , 彭　丹 , 曹思邈 , 刘宇辰 , 王鹏超^*

东北林业大学生命科学学院，黑龙江 哈尔滨 150040

摘　要：

黄酮类化合物是一种广泛存在于植物体内的次生代谢产物，有着抗病毒、抗菌、抗炎、抗癌和抗肥胖等生理活性，具有广阔的生产应用前景，但是直接从植物中提取黄酮类化合物的方法有着浓度低、提取难度大、生产周期长等问题。近年来，随着微生物代谢工程和合成生物学研究的不断深入，基于微生物合成黄酮类的生产方式可以提供一种低廉高效的替代方案。针对微生物合成黄酮类化合物，文中简述了黄酮类化合物的合成途径，总结了国内外对其生产宿主选择、前体合成优化以及微生物共培养技术等多种优化策略在黄酮类化合物生物合成中应用的研究，并对其未来发展方向进行了展望。

通讯作者：王鹏超 , Email:pengchaowang1990@163.com

Research progress on microbial synthesis of flavonoi

YANG Wen-Bo , PENG Dan , CAO Si-Miao , LIU Yu-Chen , WANG Peng-Chao^*

College of Life Sciences, Northeast Forestry University, Harbin 150040, China

Abstract:

Flavonoids are secondary metabolites that are widely found in plants and show antiviral, antibacterial, anti-inflammatory, anti-cancer and anti-obesity activities, and have broad production prospects. However, extracting flavonoids directly from plants faces problems such as low concentration, difficult extraction and long production cycle. In recent years, with the increasing research on microbial metabolic engineering and synthetic biology, the production of flavonoids based on microbial synthesis can provide a cheap and efficient alternative. In this paper, we briefly describe the synthetic pathways of flavonoids, summarize the application of various optimization strategies in the biosynthesis of flavonoids, such as host selection, precursor synthesis optimization and microbial co-culture technology at home and abroad, and provide an outlook on their future development.

Communication Author：WANG Peng-Chao , Email:pengchaowang1990@163.com