《生命科学》 2022, 34(2): 212-219

长链非编码RNA在肿瘤免疫微环境中的作用

胡诗芸 , 奕天飞 , 王家立 , 廖　奇^* , 叶　孟^*

宁波大学医学院，宁波 315211

摘　要：

长链非编码RNA (long noncoding RNAs, lncRNAs) 作为非编码RNA 的重要组成部分，可通过影响细胞因子及免疫检查点相关分子的表达来调节肿瘤微环境中多种免疫细胞的功能以及分布情况，从而重塑免疫抑制性肿瘤微环境，影响肿瘤进展，并与多种临床病理因素及预后相关。该文对lncRNAs 与肿瘤微环境中各类免疫细胞之间的相互作用关系进行了综述。

通讯作者：廖　奇 , Email:liaoqi@nbu.edu.cn 叶　孟 , Email:yemeng@nbu.edu.cn

Research progress on long noncoding RNA in tumor immune microenvironment

HU Shi-Yun , YI Tian-Fei , WANG Jia-Li , LIAO Qi^* , YE Meng^*

School of Medicine, Ningbo University, Ningbo 315211, China

Abstract:

Long noncoding RNAs (lncRNAs), as a significant part of noncoding RNAs (ncRNAs), regulate the functions and distribution of multiple immune cells in the tumor microenvironment. LncRNAs influence a number of cytokines and immune checkpoint molecules, and reshape the immunosuppressive tumor microenvironment. Also, they are relevant to clinicopathological and prognostic factors, and affect tumor progression. This review covers interactions between lncRNAs and various immune cells in tumor microenvironment.

Communication Author：LIAO Qi , Email:liaoqi@nbu.edu.cn YE Meng , Email:yemeng@nbu.edu.cn