《生命科学》 2022, 34(2): 145-154

神经系统中HCN通道及其调控分子的研究进展

吴　凡^1,2 , 舒渝茜^1,2 , 章　帆^1,2 , 鲁　娇^1,2 , 王　清^1,2 , 赵　航^1,2 , 何　治^1,2,*

¹国家中医药管理局中药药理科研三级实验室，宜昌 443002 ²三峡大学医学院，宜昌 443002

摘　要：

超极化激活的环核苷酸门控(hyperpolarization-activated and cyclic nucleotide-gated, HCN) 阳离子通道属于电压门控孔环通道超家族，并且广泛表达于心脏和中枢神经系统(central nervous system, CNS) 中。HCN 通道在膜电位超极化时被激活，并在神经系统内传导一种内向的超极化激活电流(Ih)。在CNS 中，HCN 通道的表达、分布及生理功能受到细胞内外小分子、辅助蛋白、蛋白激酶及多种神经递质的调控，并进一步影响其下游信号。该文就HCN 通道的结构及其在CNS 中的分布及调控作一综述。

通讯作者：何　治 , Email:329856208@qq.com

Research progress of HCN channels and the regulatory molecules in nervous system

WU Fan^1,2 , SHU Yu-Qian^1,2 , ZHANG Fan^1,2 , LU Jiao^1,2 , WANG Qing^1,2 , ZHAO Hang^1,2 , HE Zhi^1,2,*

¹Third-grade Pharmacological Laboratory on Traditional Chinese Medicine Approved by State Administration of Traditional Chinese Medicine, Yichang 443002, China ²Medical College, China Three Gorges University, Yichang 443002, China

Abstract:

Hyperpolarization activated and cyclic nucleotide gated (HCN) cation channels belong to the voltagegated pore ring channel superfamily and are widely expressed in the heart and central nervous system (CNS). HCN channels are activated during membrane potential hyperpolarization and conduct an inward hyperpolarization activated current (Ih) in the nervous system. In the CNS, HCN channels and their distribution and physiological functions are regulated by intracellular and extracellular small molecules, accessory proteins, protein kinases and many neurotransmitters, then affect the downstream signals. Here we review the structure, distribution and regulation of HCN channels in CNS.

Communication Author：HE Zhi , Email:329856208@qq.com