《生命科学》 2022, 34(2): 128-136

乙醛脱氢酶2与心血管疾病研究进展

费娟娟 , 张英梅 , 任　骏^*

复旦大学附属中山医院心内科，上海市心血管病研究所，上海 200032

摘　要：

尽管目前心血管疾病的诊疗技术快速发展，但心血管疾病的发病率却逐年升高。如何尽早有效预防和精准化治疗心血管疾病成为目前关注的重点。乙醛脱氢酶2 (aldehyde dehydrogenase-2, ALDH2) 是位于线粒体基质，对机体醛类物质的代谢起关键作用的催化酶类。近年来发现ALDH2 受多种因素影响及调控，尤其是东亚人群ALDH2 突变发生率高，其改变在心血管疾病发生发展中起着重要的作用。该文就ALDH2的影响因素及其在心血管疾病中的保护作用及主要机制进行综述。

通讯作者：任　骏 , Email:jren_aldh2@outlook.com

Aldehyde dehydrogenase-2 and cardiovascular disease

FEI Juan-Juan , ZHANG Ying-Mei , REN Jun^*

Department of Cardiology, Zhongshan Hospital, Fudan University, Shanghai Institute of Cardiovascular Diseases, Shanghai 200032, China

Abstract:

Despite the rapid development of cardiovascular diagnosis and treatment technology, the incidence of cardiovascular disease keeps on increasing. The effective prevention and accurate treatment of cardiovascular disease have become the current focus of attention. Aldehyde dehydrogenase-2 (ALDH2), a catalytic enzyme located in the mitochondrial matrix, plays a crucial role in the metabolism of aldehydes. It has been recently reported that ALDH2 is regulated by various factors. ALDH2 mutation, especially in East Asian population, plays an important role in the progression of cardiovascular disease. In this review, we summarize the regulating factors of ALDH2, as well as its protective role and the underlying mechanisms in cardiovascular disease.

Communication Author：REN Jun , Email:jren_aldh2@outlook.com