《生命科学》 2022, 34(1): 55-61

LncRNA介导Runx2调控骨疾病的研究进展

杨雨轩¹ , 李婷婷¹ , 张士花¹ , 元　宇^2,* , 邹　军^1,*

¹上海体育学院运动科学学院，上海 200438 ²广州体育学院运动科学学院，广州 510630

摘　要：

长链非编码RNA (long nocoding RNA, lncRNA) 是转录调控、细胞生长和分化等多种生物过程中的关键调节因子。近年有研究表明，lncRNA 能够通过骨代谢中的关键因子或者微小RNA (microRNA, miRNA) 广泛参与骨质疏松症和骨肉瘤等骨疾病的调控。Runt 相关转录因子2 (runt related transcription factor 2, Runx2) 是重要的成骨因子，在骨疾病的发生与发展和维持骨代谢稳定中有着不可或缺的作用。LncRNA 能通过Runx2 调控骨代谢并参与骨疾病的发病过程，但目前国内仍未有关于lncRNA 介导Runx2调控骨疾病的综述报道。因此，该文主要以Runx2 与骨代谢为切入点，概述lncRNA 在骨疾病中的作用，为骨疾病的靶向治疗提供一定的理论基础。

 

通讯作者：元　宇 , Email:yuanyumail@126.com 邹　军 , Email:zoujun777@126.com

Research progress in the regulation of lncRNA in bone diseases via Runx2

YANG Yu-Xuan¹ , LI Ting-Ting¹ , ZHANG Shi-Hua¹ , YUAN Yu^2,* , ZOU Jun^1,*

¹School of Kinesiology, Shanghai University of Sport, Shanghai 200438, China ²School of Kinesiology, Guangzhou Sport University, Guangzhou 510630, China

Abstract:

Long nocoding RNA (lncRNA) is emerging as key regulators in multiple biological processes, including cell differentiation and transcriptional regulation. In recent years, studies have shown that lncRNA can widely participate in the regulation of bone diseases such as osteoporosis and osteosarcoma through regulating the key factors in bone metabolism or microRNA (miRNA). Runt related transcription factor 2 (Runx2) is an important osteogenic factor, which plays an indispensable role in the occurrence and development of bone diseases. LncRNA can regulate bone metabolism and participate in the pathogenesis of bone diseases by mediating Runx2. But there are few reviews reporting that lncRNA regulates bone iseases via Runx2. Therefore, we summarize here the role of lncRNA in bone diseases from the perspective of Runx2 and bone metabolism, which may help to provide more reliable theoretical basis for the targeted therapy of bone diseases.

Communication Author：YUAN Yu , Email:yuanyumail@126.com ZOU Jun , Email:zoujun777@126.com