《生命科学》 2022, 34(1): 34-38

STAT3的非转录功能研究进展

陈艳琼 , 白秀峰^*

四川大学华西医院人类疾病和免疫治疗实验室，成都 610041

摘　要：

信号转导与转录激活因子3 (STAT3) 是重要的转录因子，通过调节下游靶基因表达对细胞活性产生影响。肿瘤及自身免疫病患者的STAT3 处于过度激活状态，据此已开发多款抑制STAT3 转录活性的抑制剂，以及靶向降解STAT3 的蛋白质水解靶向嵌合体(PROTAC) 技术。然而，除细胞核之外，STAT3 也被发现定位于线粒体、内质网及溶酶体等细胞器，并参与这些细胞器正常功能的调节，因此该综述总结了STAT3 的非转录因子功能研究进展。

通讯作者：白秀峰 , Email:baixiufeng@wchscu.cn

Research progress of the non-transcriptional functions of STAT3

CHEN Yan-Qiong , BAI Xiu-Feng^*

Laboratory of Human Disease and Immunotherapy, West China Hospital, Sichuan University, Chengdu 610041, China

Abstract:

Signal transducer and activator of transcription 3 (STAT3) is an important transcription factor that affects cell activity by regulating the expression of target genes. STAT3 is usually over-activated in tumor and autoimmune disease. A variety of inhibitors have been developed to inhibit the transcription activity of STAT3. Besides, proteolysis targeting chimera (PROTAC) targeting to degrade STAT3 has been developed. However, STAT3 has also been found to be localized in organelles such as mitochondria, endoplasmic reticulum and lysosomes, and is involved in the functional regulation of these organelles. This review summarizes the recent progressions of the non-transcription factor functions of STAT3.

Communication Author：BAI Xiu-Feng , Email:baixiufeng@wchscu.cn