《生命科学》 2022, 34(1): 16-22

蛋白质泛素化修饰在HIV-1复制中的作用研究进展

陈　帆^1,2 , 周光凤^1,2 , 熊思东^1,* , 郑永唐^2,*

¹苏州大学药学院，苏州 215021 ²中国科学院昆明动物研究所，中国科学院动物模型与人类疾病机理重点实验室，昆明 650223

摘　要：

HIV-1 是引起艾滋病大流行的主要病原体，在其与宿主相互作用的过程中，病毒运用各种手段逃避宿主的抗病毒免疫系统，而宿主同时会进化出相应的“武器”来对抗病毒的入侵。在这一系列的过程中，泛素化修饰作为一种重要的蛋白质翻译后修饰过程，在HIV-1 复制中起重要作用。同时，泛素化的可逆过程去泛素化修饰对HIV-1 的复制也具有一定的影响。该文综述了泛素化和去泛素化修饰在HIV-1 复制过程中的作用研究，有助于更好地理解宿主与HIV-1 之间的相互作用机制，为抗HIV-1 药物的研发提供新的思路。

通讯作者：熊思东 , Email:sdxiong@suda.edu.cn 郑永唐 , Email:zhengyt@mail.kiz.ac.cn

Research progress on the function of protein ubiquitination during HIV-1 replication

CHEN Fan^1,2 , ZHOU Guang-Feng^1,2 , XIONG Si-Dong^1,* , ZHENG Yong-Tang^2,*

¹College of Pharmacy, Soochow University, Suzhou 215021, China ²Key Laboratory of Animal Models and Human Disease Mechanisms of the Chinese Academy of Sciences, Kunming Institute of Zoology, Chinese Academy of Sciences, Kunming 650223, China

Abstract:

HIV-1 is the main pathogen causing the AIDS pandemic. During its interaction with the host, the virus uses various strategies to evade the host's antiviral immune system, and the host will also evolve corresponding "weapons" to fight the virus invasion. In this series of processes, ubiquitination modification, as an important protein post-translational modification process, plays an important role in HIV-1 replication. At the same time, the reversible process of ubiquitination, deubiquitination, also has a certain impact on the replication of HIV-1. This article reviews the role of ubiquitination and deubiquitination modifications in the process of HIV-1 replication, which helps to better understand the interaction mechanism between the host and HIV-1, and provides some new ideas for the development of anti-HIV-1 drugs.

Communication Author：XIONG Si-Dong , Email:sdxiong@suda.edu.cn ZHENG Yong-Tang , Email:zhengyt@mail.kiz.ac.cn