《生命科学》 2005, 17(4):

CCL27的不同剪切机制及其功能差异

邵先安，熊思东^*

复旦大学上海医学院免疫学系 教育部分子医学重点实验室 上海基因免疫与疫苗研究中心，上海 200032

摘　要：摘　要：CCL27是一种CC型趋化因子，其配体为CCR10。由于mRNA剪切的不同，CCL27形成两种不同的分子，即经典CCL27和其变异体PESKY，前者含分泌肽，对活化CD4+T细胞有趋化作用，是皮肤炎症反应中扮演主要角色的趋化因子；后者含有核内定位序列，调控细胞骨架结构的重排，这一特性为该趋化因子所独有，可能预示着趋化因子家族的新功能。
关键词：CCL27；PESKY；剪切机制；功能

Differential splicing mechanism of CCL27 and distinct consequence

SHAO Xian-An, XIONG Si-Dong^*

Department of Immunology of Shanghai Medical College of Fudan University, Key Laboratory of Molecular Medicine of Ministry of Education, Center for Gene Immunization and Vaccine Research, Shanghai 200032, China

Abstract: Abstract: CC chemokine ligand 27 (CCL27), through interaction with its cognate receptor, CC chemokine receptor 10 (CCR10), involved in attracting a subset of CD4+ T cells to the skin during some cutaneous inflammatory responses. Strangely, CCL27 can also be produced as a non-secreted form, as a result of alternative splicing. This protein, termed PESKY, is targeted to the nucleus where it is able to modulate transcription and alter cell morphology. Specifically, PESKY induces a rearrangement of the actin cytoskeleton. Such character is sole in chemokine family and may foreshow new function of chemokine in immune response.
Key words: CCL27; PESKY; splicing mechanism; function