《生命科学》 2021, 33(10): 1252-1259

NOXs在肠道微生态中的作用

刘　琪 , 聂　源 , 朱　萱^*

南昌大学第一附属医院消化内科，南昌 330006

摘　要：

NOX 家族(NADPH oxidases, NOXs)，也称还原型烟酰胺腺嘌呤二核苷酸磷酸(nicotinamide adenine dinucleotide phosphate, NADPH) 氧化酶，是催化细胞产生活性氧(reactive oxygen species, ROS) 的主要酶，参与调节细胞增殖、迁移、分化、凋亡、衰老和炎症反应等多种生理过程，对维持宿主免疫功能和调节肠道微生态至关重要。肠道微生态包括肠道菌群、肠道黏膜屏障和肠道菌群代谢物，可以调控NOXs 的激活，导致相关疾病发生发展。因此，以NOXs 作为治疗靶点具有重要的研究意义和广泛的应用前景。该文重点就肠道微生态相关NOXs 的组成和激活及其在肠道微生态中的作用进行综述。

通讯作者：朱　萱 , Email:jyyfyzx@163.com

The regulatory mechanism of NOXs in intestinal microecology 

LIU Qi , NIE Yuan , ZHU Xuan^*

Department of Gastroenterology, The First Affiliated Hospital of Nanchang University, Nanchang 330006, China

Abstract:

NOX/DUOX family, also called NADPH oxidases, are the primary enzymes for the generation of reactive oxygen species (ROS). Through producing ROS, activated NADPH oxidases participate in the regulation of cell proliferation, migration, differentiation, apoptosis, aging, inflammation and other physiological processes. Therefore, it is essential for maintaining host defenses and regulating intestinal microecology. Intestinal microecology includes intestinal flora, intestinal mucosal barrier and intestinal flora metabolites, which can regulate the activation of NOXs and lead to the development of related diseases. Targeting NOXs to regulate intestinal microecology has increasingly broad application prospects. This review focuses on the composition and activation of NOXs related to intestinal microecology, and its role in intestinal microecology regulation.

Communication Author：ZHU Xuan , Email:jyyfyzx@163.com