《生命科学》 2021, 33(9): 1188-1195

非编码RNA与瘢痕疙瘩的关系及研究进展

王剑巧 , 曹先伟 , 万　川 , 郑晓草 , 张志彬^*

南昌大学第一附属医院皮肤科，南昌 330006

摘　要：

瘢痕疙瘩是创伤后胶原纤维异常增生引起的过度纤维化疾病，病理表现主要是成纤维细胞过度增殖和细胞外基质异常沉积。然而，因瘢痕疙瘩发病机制尚不完全明确，且缺乏安全有效的治疗方法和预防策略，因此，迫切需要了解其详细的发病机制进而开发全新且安全有效的治疗方法。近年来，大量研究表明，非编码RNA 可通过直接靶向关键基因或间接参与瘢痕疙瘩形成经典信号通路影响成纤维细胞增殖、凋亡、侵袭、迁移以及胶原蛋白的异常沉积，进而调控瘢痕疙瘩的进程，同时有研究发现异常表达的非编码RNA可能为瘢痕疙瘩的治疗提供潜在靶点。该文将总结近年来非编码RNA 在瘢痕疙瘩中的研究进展及未来通过干预相关非编码RNA 来治疗瘢痕疙瘩的前景及挑战。

通讯作者：张志彬 , Email:zzbpf0624@163.com

Relationships between non-coding RNA and keloid

WANG Jian-Qiao , CAO Xian-Wei , WAN Chuan , ZHENG Xiao-Cao , ZHANG Zhi-Bin^*

Department of Dermatology, The First Affiliated Hospital of Nanchang University, Nanchang 330006, China

Abstract:

Keloid is an excessive fibrosis disease caused by abnormal proliferation of collagen fibers after trauma. The main pathological manifestations are excessive proliferation of fibroblasts and abnormal deposition of extracellular matrix. However, the pathogenesis of keloid is not fully clear, and there is a lack of safe and effective treatment and prevention strategies, so it is urgent to understand the detailed pathogenesis of keloid and develop new safe and effective treatment methods. In recent years, a large number of studies have shown that non-coding RNA directly targets key genes or indirectly participates in the classic signaling pathway of keloid formation to affect the proliferation, apoptosis, invasion, migration of fibroblast and abnormal deposition of collagen, thereby regulating the process of keloids. At the same time, studies have found that abnormally expressed non-coding RNA may provide a potential target for the treatment of keloid. This article reviews the recent researches on non-coding RNA in keloid and the future prospects and challenges of treating keloid by targeting related non-coding RNA.

Communication Author：ZHANG Zhi-Bin , Email:zzbpf0624@163.com