《生命科学》 2005, 17(4):

光亲和标记技术在药物发现中的应用

仇文卫, 李静雅，李　佳^*， 南发俊^*

中国科学院上海生命科学研究院药物研究所，国家新药筛选中心，中国科学院研究生院，上海 201203

摘　要：摘　要：功能蛋白质组学的研究在药物发现中扮演着重要的角色，而光亲和标记技术是研究功能蛋白质组学的主要策略之一，它主要有两个方面的应用：靶标蛋白的确定和活性小分子配体与靶标蛋白作用模式的揭示，这些信息为药物的发现提供了强有力的支持。
关键词：功能蛋白质组学；光亲和标记技术；靶标蛋白；药物发现

Photoaffinity labeling in drug discovery

QIU Wen-Wei, LI Jing-Ya, LI Jia^*, NAN Fa-Jun^*

The National Center for Drug Screening, Shanghai Institute of Materia Medica, Shanghai Institutes for Biological Sciences, Chinese Academy of Sciences, Graduate School of the Chinese Academy of Sciences, Shanghai 201203, China

Abstract:

Abstract: Photoaffinity labeling technology is one of the major strategy of functional proteomics which plays a key role in drug discovery currently, it has two aspects in application: identification of target proteins and give the structural information at the contact point of drugs with receptors, these information give a tremendous promotion of drug discovery.
Key words: functional proteomics; photoaffinity labeling technology; target proteins; drug discovery