《生命科学》 2021, 33(9): 1082-1088

牛磺酸调节巨噬细胞功能的研究进展

欧　曈¹ , 郭鑫哲¹ , 陈　文^1,2 , 郭俊霞^1,2,*

¹北京联合大学生物活性物质与功能食品北京市重点实验室，北京 100191 ²北京联合大学生物化学工程学院食品科学系，北京 100023

摘　要：

牛磺酸(Taurine) 是机体内分布广泛且具有众多生理功能的含硫氨基酸，近年来牛磺酸对慢性炎症性疾病具有潜在的防治功能已得到广泛认可。巨噬细胞是参与慢性炎症的重要免疫细胞，其牛磺酸含量细胞内比细胞外高出约100 倍。大量研究集中在补充牛磺酸可明显改善“ 无菌性炎症”疾病引起的巨噬细胞聚集和炎症反应。该文就牛磺酸体内水平及其变化、摄入安全性以及对巨噬细胞免疫功能的调节等方面的研究进行了综述，以期为牛磺酸免疫营养分子机制的深入研究和功能食品领域的开发提供参考。

通讯作者：郭俊霞 , Email:junxia@buu.edu.cn

Research progress of taurine regulating macrophage functions

OU Tong¹ , GUO Xin-Zhe¹ , CHEN Wen^1,2 , GUO Jun-Xia^1,2,*

¹Beijing Key Laboratory of Bioactive Substances and Functional Foods, Beijing Union University, Beijing 100191, China ²Department of Food Science, Beijing Union University, Beijing 100023, China

Abstract:

Taurine is the most abundant sulfur-containing amino acid in mammalian tissues and plays an essential role in many biological processes. Taurine has been widely evaluated as a potential therapeutic agent in chronic inflammatory disorders. Macrophages are important immune effector cells in inflammation response, in which the intracellular taurine level is about 100 times higher than the extracellular one. Recent research focused on that taurine supplementation significantly improved the inflammatory response of macrophages in "sterile inflammatory" diseases. In this review, studies on the taurine level and its changes in vivo, safety evaluation of taurine, and the regulation of taurine on macrophage functions are reviewed to provide references for further research on the molecular mechanism of taurine immune nutrition and the development of functional foods.

Communication Author：GUO Jun-Xia , Email:junxia@buu.edu.cn