《生命科学》 2021, 33(9): 1063-1070

富含鸟嘌呤序列的RNA结合因子(GRSF1)研究进展

孔丽君 , 曹思邈 , 刘姝晗 , 刘梦轻 , 梁　洋^*

东北林业大学生命科学学院，哈尔滨 150040

摘　要：

富含鸟嘌呤序列的 RNA 结合因子1 (GRSF1) 是RNA 结合蛋白，属于异质核核糖核酸蛋白(hnRNP)F/H 家族，该蛋白家族成员均含有两个以上类RNA 识别基序(qRRMs) 和至少一个辅助结构域。qRRM ( 类RNA 识别基序) 与RRM (RNA 识别基序) 相似但作用方式不同。在发育、衰老、肿瘤等领域，GRSF1 发挥着重要作用。随着生物信息学和测序技术的发展，GRSF1 的功能和作用机制被逐渐揭示，但并未得到充分解析。该文对GRSF1 结构特点、表达调控和作用机制进行了概述，并总结了其在发育、细胞衰老、肿瘤发生等领域的研究进展，为深入探究GRSF1 的作用机制及挖掘其生物功能奠定基础。

通讯作者：梁　洋 , Email:liang11yang@126.com

Research progress of guanine-rich RNA sequence binding factor 1 (GRSF1)

KONG Li-Jun , CAO Si-Miao , LIU Shu-Han , LIU Meng-Qing , LIANG Yang^*

School of Life Sciences, Northeast Forestry University, Harbin 150040, China

Abstract:

The guanine-rich RNA sequence binding factor 1 (GRSF1) is an RNA-binding protein belonging to the heterogeneous nuclear ribonucleoprotein (hnRNP) F/H family. Each member of this protein family contains more than two quasi-RNA recognition motifs (qRRMs) and at least one helper domain. qRRM (quasi-RNA recognition motif) is similar to RRM (RNA recognition motif) but acts in different ways. GRSF1 plays an important role in development, senescence, tumorigenesis and other fields. With the development of bioinformatics and sequencing technology, the functions and mechanisms of GRSF1 have been gradually revealed, but not fully resolved. In this review, we summarize the structural characteristics, expression regulation, the molecular mechanism and the research progress of GRSF1 in the fields of development, cell senescence, and tumorigenesis, which lays a foundation for exploring the mechanism of action and biological function of GRSF1.

Communication Author：LIANG Yang , Email:liang11yang@126.com