《生命科学》 2021, 33(8): 1018-1027

miR-338-5P在人类恶性肿瘤等疾病中的作用和应用

付岩松^1,2 , 郭志涛^1,2 , 陈　晨^1,2 , 孟祥宁^1,2 , 朱　静^1,2,*

¹哈尔滨医科大学医学遗传学研究室，哈尔滨 150081 ²中国遗传资源保护与 疾病防控教育部重点实验室(哈尔滨医科大学)，哈尔滨 150081

摘　要：

微小RNA (microRNA, miRNA) 是一类由19~24 个核苷酸构成的内源性的非编码单链RNA，通过与靶基因完全或不完全结合降解mRNA 或抑制mRNA 的翻译，在体内起到转录后调控作用，参与多种生理和病理过程。新近报道发现，miR-338-5P 在黑色素瘤、消化系统肿瘤、肺癌等各种类型的癌症中异常表达，其通过结合一系列的靶基因来调控细胞增殖、转移、侵袭和凋亡，在不同肿瘤中发挥抑癌或促癌的不同作用，并可能成为癌症诊断的生物标志物和治疗靶点。在其他炎性相关疾病中，比如病理性心肌肥厚、类风湿性关节炎等，也发现miR-338-5P 可以通过靶向不同基因，参与疾病的发生发展。现综述miR-338-5P 在肿瘤、肿瘤放化疗以及其他炎性相关疾病中的作用和其在疾病诊断、预后判断等方面的应用，为肿瘤等疾病相关标志物以及更有效的治疗靶点的开发提供新思路。

通讯作者：朱　静 , Email:zhuj@hrbmu.edu.cn

Roles and application potentials of miR-338-5P in human cancers and other diseases

FU Yan-Song^1,2 , GUO Zhi-Tao^1,2 , CHEN Chen^1,2 , MENG Xiang-Ning^1,2 , ZHU Jing^1,2,*

¹Laboratory of Medical Genetics, Harbin Medical University, Harbin 150081, China ²Key Laboratory of Preservation of Human Genetic Resources and Disease Control in China (Harbin Medical University), Ministry of Education, Harbin 150081, China

Abstract:

MicroRNA (miRNA) is a class of endogenous non-coding single-stranded RNA composed of 19-24 nucleotides. By completely or partially binding to target mRNAs to degrade mRNA or inhibit protein expression, miRNA plays a role in post-transcriptional expression regulation in vivo and is involved in various physiological and pathological processes. New reports found that miR-338-5P is abnormally expressed in melanoma, digestive system tumors, lung cancer and other types of cancers, playing diverse roles through the binding to a series of target genes to regulate cell proliferation, metastasis, invasion and apoptosis in the different background as a tumor suppressor or promoter, and may become cancer biomarkers and therapeutic targets. In other inflammatory diseases, such as pathological cardiac hypertrophy and rheumatoid arthritis, miR-338-5P has also been found to be involved in the occurrence and development of diseases by targeting different genes. The function and application potentials of miR-338-5P in human diseases, including tumors and other inflammatory diseases, were reviewed to provide new ideas for the development of disease diagnosis, prognostic biomarkers and more effective therapeutic targets.

Communication Author：ZHU Jing , Email:zhuj@hrbmu.edu.cn