《生命科学》 2021, 33(8): 989-996

花生四烯酸CYP450代谢与非酒精性脂肪肝及其运动干预研究进展

赵　格 , 杨文琦 , 刘　玲 , 李亚平 , 李良鸣^*

广州体育学院，广州 510500

摘　要：

非酒精性脂肪肝病(nonalcoholic fatty liver disease, NAFLD) 是一种常见的慢性代谢性肝病，是代谢综合征在肝脏的疾病表现，其发病率在全球范围内逐年增加。花生四烯酸(arachidonic acid, AA) 是一种ω-6多不饱和脂肪酸，主要以磷脂的形式存在于细胞膜上，在肝脏中发挥重要的生物学作用。AA 的细胞色素P450 (cytochrome P450, CYP450) 代谢及其代谢产物广泛参与脂质代谢紊乱、炎症反应、氧化应激、内质网应激等病理过程，在NAFLD 发生发展中的作用逐渐引起关注。运动是防治NAFLD 的有效方法，可能通过改善AA 的CYP450 代谢发挥作用，但尚缺乏直接证据。

通讯作者：李良鸣 , Email:liangming12j@126.com

Research progress on the role of arachidonic acid CYP450 metabolism in nonalcoholic fatty liver and the exercise intervention

ZHAO Ge , YANG Wen-Qi , LIU Ling , LI Ya-Ping , LI Liang-Ming^*

Guangzhou Sports University, Guangzhou 510500, China

Abstract:

Nonalcoholic fatty liver disease (NAFLD) is a common chronic metabolic liver disease, which is a manifestation of metabolic syndrome in the liver. The incidence of NAFLD is increasing globally. Arachidonic acid (AA) belongs to ω-6 polyunsaturated fatty acid, which mainly exists on the cell membrane in the form of phospholipids and plays an important biological role in the liver. The CYP450 metabolism of AA is widely involved in the pathological processes of NAFLD, such as lipid metabolic disorders, inflammatory reactions, oxidative stress, endoplasmic reticulum stress. Exercise is an effective strategy for the prevention and treatment of NAFLD. Although there is no direct evidence, some studies indicate that exercise may play a role in improving the CYP450
metabolism of AA.

Communication Author：LI Liang-Ming , Email:liangming12j@126.com