《生命科学》 2021, 33(8): 979-988

m⁶A修饰的调控机制及其在发育和干细胞中的功能研究进展

张璐纯 , 袁　梦 , 曹芊梓 , 黄星卫 , 雷　蕾^*

哈尔滨医科大学组织学与胚胎学教研室，哈尔滨 150081

摘　要：

N⁶- 甲基腺嘌呤 (m⁶A) 作为真核生物RNA 上的一种重要的表观遗传修饰，拥有众多的识别蛋白，形成了复杂多样的调控网络，在调控生物体的生长发育以及疾病的发生中有着重要的作用。该文对m⁶A 以及其检测方法和阅读蛋白进行简要介绍，着重讨论了m⁶A 在干细胞干性维持以及胚胎发育中的生物学功能，总结了m⁶A 与其他分子修饰的联系，讨论了rRNA 上的m⁶A 修饰，最后对m⁶A 可能参与的其他生物学过程进行了展望。

通讯作者：雷　蕾 , Email:lei086@ems.hrbmu.edu.cn

Research progress on the regulatory mechanism of m⁶A modification and its functions in development and stem cells

ZHANG Lu-Chun , YUAN Meng , CAO Qian-Zi , HUANG Xing-Wei , LEI Lei^*

Department of Histology and Embryology, Harbin Medical University, Harbin 150081, China

Abstract:

N⁶-methyladenosine (m⁶A) is one of the most important epigenetic modifications on eukaryotic RNAs. It is identified by many proteins and forms a complex network, which plays crucial roles in regulating development and diseases. In this review, we briefly introduced the concept of m⁶A and its readers, as well as its detection methods. Furthermore, we emphasized on the m⁶A’s biological functions in stemness maintenance and embryo development, summarized the connections between m⁶A and other modifications, then discussed the effect of m⁶A in rRNA. In the end, we prospected other processes that m⁶A may participate in.

Communication Author：LEI Lei , Email:lei086@ems.hrbmu.edu.cn