《生命科学》 2021, 33(8): 921-930

IL-34在中枢神经系统疾病中的作用

王　申¹ , 黄　曼^2,*

¹浙江大学医学院，杭州 310058 ²浙江大学附属第二医院，杭州 310052

摘　要：

白介素家族一直以来都受到广泛关注，其中白介素34 (interleukin-34, IL-34) 是2008 年发现的一种新型细胞因子，是巨噬细胞集落刺激因子1 受体(macrophage colony-stimulating factor-1 receptor, CSF-1R) 的第二个配体。IL-34 是单核巨噬细胞系增殖、分化等一系列生命活动的关键调节剂。由于IL-34 在脑内的特异性表达以及其对小胶质细胞增殖、发育、维持的关键性作用，越来越多的研究聚焦于IL-34 在中枢神经系统疾病中的作用。IL-34 在神经退行性疾病、脱髓鞘疾病、病毒感染和作为中枢系统疾病研究工具中的作用受到广泛关注。该文综述了IL-34 的生物学特性，以及IL-34 在中枢神经系统疾病研究中的重要作用。

通讯作者：黄　曼 , Email:huangman@zju.edu.cn

The role of IL-34 in central nervous system diseases

WANG Shen¹ , HUANG Man^2,*

¹School of Medicine, Zhejiang University, Hangzhou 310058, China ²The Second Affiliated Hospital of Zhejiang University, Hangzhou 310052, China

Abstract:

Interleukin-34 (IL-34), a novel cytokine discovered in 2008, was identified as the second ligand of the macrophage colony-stimulating factor-1 receptor (CSF-1R). IL-34 is a key regulator of monocyte-macrophage lineage proliferation, differentiation and a series of life activities. Due to the specific expression of IL-34 in the brain and its key role in the proliferation, development and maintenance of microglia, more and more studies have focused on the role of IL-34 in central nervous system diseases. The role of IL-34 in neurodegenerative diseases, demyelinating diseases, viral infections, and as a research tool for diseases of the central system has received
widespread attention. In this paper, we reviewed the biological characteristics of IL-34 and the important role of IL-34 in central nervous system diseases.

Communication Author：HUANG Man , Email:huangman@zju.edu.cn