《生命科学》 2021, 33(7): 896-902

DNA甲基化在克罗恩病中的调控作用

李玉龙¹ , 许宇静² , 邓　勖¹ , 魏敏惠^1,*

¹陕西中医药大学基础医学院，咸阳 712046 ²西安交通大学电气学院，西安 710049

摘　要：

克罗恩病(Crohn’s disease, CD) 是一种慢性、反复发作的多病因肠道异质性疾病。在此过程中，CD 可显著改变肠道黏膜组织形态及炎症相关基因的甲基化水平，并可影响血细胞炎症基因的甲基化修饰，进而调控相关基因的表达并诱导CD 相关的炎症、黏膜损伤等病理反应，这也意味着特定位点的DNA 甲基
化可作为CD 诊疗的潜在分子靶标。该文将综合阐述CD 与DNA 甲基化修饰的相关性及DNA 甲基化作为CD 诊断分子标记的可行性。

通讯作者：魏敏惠 , Email:2111027@sntcm.edu.cn

The regulatory effects of DNA methylation on Crohn’s disease

LI Yu-Long¹ , XU Yu-Jing² , DENG Xu¹ , WEI Min-Hui^1,*

¹College of Basic Medical Science, Shaanxi University of Chinese Medicine, Xianyang 712046, China ²Xi’an Jiaotong University, Xi’an 710049, China

Abstract:

Crohn’s disease (CD) is a heterogeneous group of multicausal intestinal disease that is characterized by chronic and frequently recurrence, which could further lead to the pathological symptoms of gut inflammation and intestinal mucosal injury. In this process, CD significantly affects the DNA methylation patterns of genes related to intestinal mucosal morphology and inflammatory response in intestinal mucosa, as well, modulates the methylation of inflammatory genes in hemocytes. These methylation alterations will further affect the expression of corresponding genes, and activate the pathological reactions of CD. This means that DNA methylation is a potential molecular marker of CD diagnosis and treatment. In this review, we summarize and discuss the correlation between CD and DNA methylation, as well as the potential medicinal value of DNA methylation in CD diagnosis.

Communication Author：WEI Min-Hui , Email:2111027@sntcm.edu.cn