《生命科学》 2021, 33(7): 853-860

骨外器官来源外泌体对骨骼调控作用的研究进展

吴阳明 , 刘承宜 , 张玲莉^*

华南师范大学体育科学学院，广州 510006

摘　要：

外泌体是细胞分泌外囊泡中研究最为广泛的三个主要亚群之一，在介导细胞间信息交流过程中发挥着至关重要的作用，其跨器官调控和远距离调控的特点也是外泌体相关研究备受瞩目的原因之一。近年来，外泌体调节骨稳态以及介导肿瘤细胞骨转移的相关研究逐渐增多，然而骨外来源外泌体对骨骼细胞的调控作用虽有较多研究，但对其调控活动网络的梳理尚不清晰。该文通过总结骨外来源外泌体对骨骼的调控作用，梳理和完善骨外器官和组织分泌的外泌体对骨骼的调控活动网络，为探究不同来源外泌体改善骨微环境，抵抗肿瘤细胞骨转移提供理论依据。

通讯作者：张玲莉 , Email:lingliwdc@163.com

Advances in the study of skeletal regulation by exosomes of extraosseous organ origin

WU Yang-Ming , LIU Cheng-Yi , ZHANG Ling-Li^*

School of Physical Education, South China Normal University, Guangdong 510006, China

Abstract:

Exosomes are one of the three most widely studied subpopulations of extracellular secretory vesicles, and play a crucial role in mediating intercellular information exchange, and their trans-organ regulation and long-range regulation are one of the reasons why exosome-related tudies have attracted much attention. In recent years, studies related to the regulation of bone homeostasis by exosomes and the mediation of bone metastasis by tumor cells have gradually increased. Although there are more studies on the regulation of skeletal cells by exosomes of extracellular origin, the network of their regulatory activities is still unclear. In this article, we summarize the regulatory effects of extraosseous exosomes on bone, and sort out the regulatory activity network of exosomes secreted by extraosseous organs and tissues, so as to provide a theoretical basis for improving bone microenvironment and resisting bone metastasis of tumor cells by different sources of exosomes.

Communication Author：ZHANG Ling-Li , Email:lingliwdc@163.com