《生命科学》 2021, 33(7): 817-823

G-四链体在卵巢癌治疗中的研究进展

杨　腾 , 徐偲蓓 , 陈文斌 , 施泓亦 , 郑小辉^*

温州医科大学药学院，温州 325035

摘　要：

卵巢癌(ovarian cancer, OC) 是最常见的女性恶性肿瘤之一，缺乏有效的治疗手段是导致卵巢癌高死亡率的主要原因之一。DNA G- 四链体(G4) 是富含鸟嘌呤碱基的一种特殊核酸结构，该结构广泛存在于端粒、原癌基因启动子等区域，是目前抗肿瘤药物设计的重要靶点。此外，有研究表明，DNA G4 可能还
存在于炎症基因的启动子区域，进而参与炎症反应的调控。鉴于炎症反应在卵巢癌进展中的重要作用，DNA G4 在卵巢癌治疗中可能具有抗肿瘤、抗炎的双重治疗效果。该文重点综述了DNA G4 及其稳定剂在卵巢癌治疗中的最新研究进展。

 

通讯作者：郑小辉 , Email:zhengxh@wmu.edu.cn

Advances in research of DNA G-quadruplex in treatment of ovarian cancer 

YANG Teng , XU Si-Bei , CHEN Wen-Bin , SHI Hong-Yi , ZHENG Xiao-Hui^*

School of Pharmaceutical Science, Wenzhou Medical University, Wenzhou 325035, China

Abstract:

Ovarian cancer (OC), which is one of the most common gynecological malignant tumors, is the most lethal cancer of the female due to the lack of effective treatment. DNA G-quadruplex (G4), which is formed by guanine-rich DNA sequences, is an important target for anti-tumor drugs. Besides in telomere and oncogene promoter, DNA G4 also had been found in inflammatory gene, regulating the inflammatory response. As inflammatory response plays an important role in the progress of ovarian cancer, DNA G4 might obtain anti-tumor and anti-inflammatory dual effects on ovarian cancer treatment. This review focuses on the recent research progress of DNA G4 and its stabilizer in the treatment of ovarian cancer.

 

Communication Author：ZHENG Xiao-Hui , Email:zhengxh@wmu.edu.cn