《生命科学》 2021, 33(6): 752-758

PDCD5在自身免疫性疾病中的调控作用及其机制

刘佩军^1,2 , 黄艳丽^1,2 , 毛　春^1,2 , 郭雅碧^1,2 , 肖　娟^1,2,*

¹湖北文理学院附属医院，襄阳市中心医院，襄阳 441021 ²湖北文理学院医学院分子医学实验室，襄阳 441053

摘　要：

程序性细胞死亡分子5 (programmed cell death 5, PDCD5) 是PDCD 家族的重要成员之一，具有多种生物学活性，如程序性细胞死亡、细胞周期、胚胎发育以及免疫调节等。PDCD5 的表达受多种因素调控，能够通过PDCD5-TIP60-FOXP3 途径促进调节性T 细胞功能。临床研究证实PDCD5 在多种自身免疫病患者的外周血、组织液及组织器官中表达异常，且与疾病的发生发展密切相关。该综述聚焦 PDCD5 对自身免疫性疾病的影响以及分子调控机制。

通讯作者：肖　娟 , Email:ju_126@126.com

Regulatory effect and the molecular mechanism of PDCD5 in autoimmune diseases

LIU Pei-Jun^1,2 , HUANG Yan-Li^1,2 , MAO Chun^1,2 , GUO Ya-Bi^1,2 , XIAO Juan^1,2,*

¹Xiangyang Central Hospital, Affiliated Hospital of Hubei University of Arts and Science, Xiangyang 441021, China ²Department of Molecular Medicine Laboratory, Medical College of Hubei University of Arts and Science, Xiangyang 441053, China

Abstract:

Programmed cell death 5 (PDCD5) is one of the important members of the PDCD family. It has been shown to be involved in a variety of biological activities, including programmed cell death, cell cycle, embryonic development and immunomodulation. PDCD5 expression is regulated by many factors. It promotes regulatory T cell function via the PDCD5-TIP60-FOXP3 pathway. Clinical studies have confirmed that PDCD5 is abnormally expressed in the peripheral blood, tissue fluid and organs of patients with a variety of autoimmune diseases. This review focuses on the effects of PDCD5 on autoimmune diseases and the underlying molecular mechanism.

Communication Author：XIAO Juan , Email:ju_126@126.com