《生命科学》 2021, 33(6): 742-751

KDM4A的结构、功能及其在肿瘤中作用的研究进展

季　涛 , 燕晓霞 , 韩兵社 , 张俊芳^*

上海海洋大学水产种质资源发掘与利用教育部重点实验室，水产科学国家级 实验教学示范中心，科技部海洋生物科学国际联合研究中心，上海 201306

摘　要：

组蛋白甲基化是一种重要的表观遗传修饰，而赖氨酸特异性去甲基化酶4A (KDM4A，也称JMJD2A) 能特异性催化组蛋白赖氨酸残基的去甲基化过程，从而调节染色质的结构和基因转录。近年来研究发现，KDM4A 参与调控了细胞增殖、分化、发育、代谢等多种重要的生物学进程，其功能异常也和肿瘤等疾病的发生发展密切相关，成为未来肿瘤治疗的重要靶点。KDM4A 在肿瘤中的作用是目前的研究热点，该文就KDM4A 的结构、作用机制、生物学功能、在肿瘤中作用及抑制剂开发的最新研究进展作一综述。

通讯作者：张俊芳 , Email:jfzhang@shou.edu.cn

Advances in the structure and functions of KDM4A and its roles in cancer

JI Tao , YAN Xiao-Xia , HAN Bing-She , ZHANG Jun-Fang^*

Key Laboratory of Aquatic Germplasm Resources Exploration and Utilization of Ministry of Education, National Experimental Teaching Demonstration Center of Aquatic Science, International Joint Research Center for Marine Biological Sciences of Ministry of Science and Technology of China, Shanghai Ocean University, Shanghai 201306, China

Abstract:

Histone methylation is an important epigenetic modification, and lysine (K)-specific demethylase 4A (KDM4A, also known as JMJD2A) specifically catalyzes the demethylation of lysine residues of histone proteins, thereby regulating chromatin structure and gene transcription. Recent studies have showed that KDM4A is involved in the regulation of multiple processes including cell proliferation, differentiation, development, and metabolism. Dysregulation of KDM4A is closely related to the onset and development of malignant tumors, making KDM4A a promising target for anti-cancer therapy. Therefore, KDM4A has been becoming a hot topic in cancer research. In this review, we discuss the structure, regulation, catalytic activity, and biological functions of KDM4A, as well as its roles in cancer treatment.

Communication Author：ZHANG Jun-Fang , Email:jfzhang@shou.edu.cn