《生命科学》 2021, 33(6): 709-717

组蛋白修饰在卵母细胞发育中功能和调控机制的研究进展

刘琳琳^1,2 , 杜鸿斌^1,2 , 孙梦莹^1,2 , 丁　悦¹ , 鞠吉雨¹ , 赵春玲^1,3,* , 田春艳^2,*

¹潍坊医学院山东省高校免疫学重点实验室，潍坊 261053 ²军事科学院军事医学研究院生命组 学研究所，北京 102206 ³潍坊医学院山东省高校生物药物重点实验室，潍坊 261053

摘　要：

组蛋白修饰作为表观遗传调控网络的重要组成部分，其主要的修饰类型包括乙酰化、甲基化、磷酸化等，在卵母细胞减数分裂过程中呈现动态变化。在卵母细胞发育过程中，表观遗传调控因子涉及的乙酰化、甲基化维持、磷酸化和组蛋白置换调控着卵母细胞减数分裂过程中基因的表达、纺锤体的组装、染色体的排列和基因组的稳定性，确保了卵母细胞减数分裂的正常进行和卵母细胞的正常发育。该文对卵母细胞发育过程中组蛋白修饰的变化、功能和调控机制的研究进展进行综述。

通讯作者：赵春玲 , Email:zhaochunlingbj@163.com 田春艳 , Email:tianchunyan@ncpsb.org

Function and regulatory mechanism of histone modifications during oocyte development

LIU Lin-Lin1^1,2 , DU Hong-Bin^1,2 , SUN Meng-Ying^1,2 , DING Yue¹ , JU Ji-Yu¹ , ZHAO Chun-Ling^1,3,* , TIAN Chun-Yan^2,*

¹Shandong University Key Laboratory of Immunology, Weifang Medical University, Weifang 261053, China ²State Key Laboratory of Proteomics, Beijing Proteome Research Center, National Center for Protein Sciences (Beijing), Beijing Institute of Lifeomics, Beijing 102206, China ³Shandong University Key Laboratory of Biopharmaceuticals, Weifang Medical University, Weifang 261053, China

Abstract:

Histone modifications, as an important part of the epigenetic regulatory network, including acetylation, methylation, phosphorylation, etc., show dynamic changes during oocyte meiosis. During oocyte development process, epigenetic regulation factor-related acetylation, methylation maintenance, phosphorylation and histone exchange regulate the expression of genes in the process of meiosis, spindle assembly, the arrangement of chromosome and genome stability, ensuring the normal oocyte meiosis and oocyte development. This review summarized the research progress of the dynamics, functions and regulation of histone modifications during oocytes development.

Communication Author：ZHAO Chun-Ling , Email:zhaochunlingbj@163.com TIAN Chun-Yan , Email:tianchunyan@ncpsb.org