《生命科学》 2021, 33(6): 702-708

Cofilin-1在细胞核中的功能研究进展

赵子婷^1,2 , 许丽艳^1,2 , 李恩民^1,2,*

¹汕头大学医学院生物化学与分子生物学教研室，汕头 515041 ²汕头大学医学院基础医学研究所，汕头 515041

摘　要：

Cofilin-1 是一种肌动蛋白结合蛋白，主要通过切割肌动蛋白丝对细胞骨架进行动态重组，维系细胞内多种分子事件的有序进行。近年来，随着肌动蛋白在细胞核内的功能被逐步揭示，Cofilin-1 作为肌动蛋白丝的关键调节因子之一，其在细胞核中的功能受到了广泛关注。该文通过系统阐述Cofilin-1 在细胞核中的功能，如介导肌动蛋白入核，参与调控细胞核形状、染色体组织、基因转录、DNA 损伤修复和细胞凋亡等，以期为深入研究Cofilin-1 及其相关功能分子探索新的发展方向。

通讯作者：李恩民 , Email:nmli@stu.edu.cn

Research progress on the function of Cofilin-1 in nucleus

ZHAO Zi-Ting^1,2 , XU Li-Yan^1,2 , LI En-Min^1,2,*

¹Department of Biochemistry and Molecular Biology, Shantou University Medical College, Shantou 515041, China ²Institute of Basic Medicine, Shantou University Medical College, Shantou 515041, China

Abstract:

Cofilin-1 is an important actin-binding protein, whose primary function is dynamic reorganization of actin cytoskeleton by severing actin filaments to ensure various intracellular processes orderly. In recent years, as the function of actin in the nucleus has been gradually revealed, Cofilin-1, one of the key regulatory factors of actin filaments, has attracted extensive attention in the function of the nucleus. Here, the latest functions of Cofilin-1 in the nucleus are reviewed, such as mediating actin into the nucleus, regulating nuclear shaping, chromatin organization, apoptosis, gene transcription and DNA damage repair, etc., which will provide a new insight for the further study of Cofilin-1 and its related molecules.

Communication Author：LI En-Min , Email:nmli@stu.edu.cn