《生命科学》 2021, 33(5): 605-610

mGluRs调节皮层-纹状体突触可塑性与运动防治帕金森病的研究进展

时凯旋¹ , 牟　彬¹ , 曾　卫¹ , 侯莉娟^2,*

¹中国地质大学(北京)体育部，北京 100083 ²北京师范大学体育与运动学院，北京 100875

摘　要：

皮层- 纹状体谷氨酸(glutamate, Glu) 能通路的异常兴奋是帕金森病(Parkinsonʹs disease, PD) 的关键病理基础。代谢性谷氨酸受体(metabotropic glutamate receptors, mGluRs) 可通过调节突触前Glu 释放和突触后传递调控皮层- 纹状体突触可塑性，是PD 临床治疗的重要干预靶点。运动疗法作为PD 康复的重要手段，可显著减缓PD 运动和认知的退变，其机制可能与重塑皮层- 纹状体突触结构与功能有关。该文就mGluRs 调控皮层- 纹状体通路Glu 传导与运动防治PD 的神经生物学机制等方面进行综述。

通讯作者：侯莉娟 , Email:houlj@bnu.edu.cn

mGluRs-mediated plasticity of corticostriatal pathway and the progress on exercise prevention of Parkinson's disease

SHI Kai-Xuan¹ , MOU Bin¹ , ZENG Wei¹ , HOU Li-Juan^2,*

¹College of P.E and Sports, Beijing Normal University, Beijing 100875, China ²Department of Physical Education, China University of Geosciences, Beijing 100083, China

Abstract:

Hyperexcitability in the corticostriatal glutamatergic pathway may play a pivotal role in the pathogenesis of Parkinson's disease (PD). Metabotropic glutamate receptors (mGluRs) modulate glutamate transmission by both pre- and postsynaptic mechanisms, making them attractive targets for modifying pathological changes in the corticostriatal pathway. Exercise reportedly alleviates motor and cognitive dysfunction via inducing neuroplasticity in corticostriatal synaptic junction. Here, the mGluR-mediated glutamatergic transmission in corticostriatal pathway and the plasticity mechanism underlying behavioral improvement by exercise intervention was reviewed.

Communication Author：HOU Li-Juan , Email:houlj@bnu.edu.cn