《生命科学》 2021, 33(4): 527-533

肺干/祖细胞代谢与呼吸系统疾病研究进展

赵付孝囡 , 王建海 , 陈怀永^*

天津医科大学海河临床学院，天津市肺脏再生医学重点实验室，天津 300350

摘　要：

呼吸系统疾病的全球死亡率居高不下，多种疾病至今仍缺乏根治手段。其中，肺癌、哮喘、特发性肺纤维化和慢性阻塞性肺疾病等难治性疾病都与肺干/祖细胞的调节和功能异常密切相关。在呼吸系统中，不同区域分布着不同类型的肺干/祖细胞。肺干/祖细胞具有自我更新、增殖与分化功能，肺部的损伤修复离不开肺干/祖细胞的这些功能。因此，负责肺脏再生的肺干/祖细胞受到越来越多的关注。研究表明，肺干/祖细胞的功能与糖酵解、脂质合成、磷酸戊糖途径、氨基酸代谢和氧化磷酸化等主要代谢途径密切相关，其代谢发生改变可能与肺脏衰老和多种呼吸系统疾病有关。该文对正常、衰老和疾病状态下的肺干/祖细胞的代谢调控进行了综述。

通讯作者：陈怀永 , Email:huaiyong.chen@foxmail.com

Metabolic regulation of lung stem/progenitor cells and respiratory diseases

ZHAO Fu-Xiao-Nan , WANG Jian-Hai , CHEN Huai-Yong^*

Tianjin Key Laboratory of Lung Regenerative Medicine, Haihe Clinical College of Tianjin Medical University, Tianjin 300350, China

Abstract:

The global mortality rate of respiratory diseases remains high. Among them, refractory diseases such as lung cancer, asthma, idiopathic pulmonary fibrosis and chronic obstructive pulmonary disease are all closely related to the altered regulation and functional abnormalities of lung stem/progenitor cells. Lung stem/progenitor cells are region-specific and exhibit the ability to self-renew, proliferate and differentiate, contributing to the repair of epithelium after lung injury. Therefore, lung stem/progenitor cells have attracted more and more attention. Previous studies have shown that the fate and the function of lung stem/progenitor cells are regulated by metabolic pathways including glycolysis, lipid synthesis, pentose phosphate pathway, amino acid metabolism, oxidative phosphorylation and other major metabolic pathways. In addition, there are many links between metabolic pathways and functions of lung stem/progenitor cells. Metabolic alteration in lung stem/progenitor cells may be related to lung aging and diseases. This article reviews the metabolic regulation of lung stem/progenitor cells under normal, aging and disease states.

Communication Author：CHEN Huai-Yong , Email:huaiyong.chen@foxmail.com