《生命科学》 2021, 33(4): 512-517

TIGAR在脑缺血中作用的研究进展

赵　航¹ , 陈　静¹ , 杨丹丹^1,2,*

¹三峡大学医学院，宜昌 443002 ²三峡大学第二人民医院，宜昌 443002

摘　要：

TP53 诱导的糖酵解和凋亡调节剂(TP53-induced glycolysis and apoptosis regulator, TIGAR) 是参与p53 引起的糖酵解和凋亡的重要因素，其与代谢稳态关系密切。TIGAR 可通过减轻氧化应激、自噬、凋亡、炎症以及线粒体功能障碍来减轻缺血性脑损伤，发挥神经保护作用。现就TIGAR 的基本信息、调节因素以及其在脑缺血中的作用进行综述，为脑缺血的预防和治疗提供理论依据。

通讯作者：杨丹丹 , Email:1546272992@qq.com

Research progress of the role of TIGAR in cerebral ischemia

ZHAO Hang¹ , CHEN Jing¹ , YANG Dan-Dan^1,2,*

¹Medical College, China Three Gorges University, Yichang 443002, China ²The Second Renmin Hospital, China Three Gorges University, Yichang 443002, China

Abstract:

TP53-induced glycolysis and apoptosis regulator (TIGAR) is an important factor involved in glycolysis and apoptosis caused by p53, and it is also closely related to metabolic homeostasis. TIGAR can reduce ischemic brain injury and exert neuroprotective effects by reducing oxidative stress, autophagy, apoptosis, inflammation, and mitochondrial dysfunction. This article summarizes basic information and regulatory factors of TIGAR, and its role in cerebral ischemia to provide a theoretical basis for the prevention and treatment of cerebral ischemia.

Communication Author：YANG Dan-Dan , Email:1546272992@qq.com