《生命科学》 2021, 33(4): 479-489

新型类石墨烯二维纳米材料应用于肿瘤光声成像的研究进展

李金玲 , 卢新良 , 符雅薇 , 刘金文^* , 刘斯佳^*

广西医科大学基础医学院，广西-东盟重大疾病防治协同创新中心，南宁 530021

摘　要：

光声成像是一种新兴的非侵入式的生物成像方式，具有极高的空间分辨率和良好的成像对比度，已逐步应用于肿瘤成像诊断基础研究。光声成像主要依赖于光声信号转换，而光声信号转换能力主要取决于造影剂的选择。近年来，随着无机纳米材料在生物医学成像领域的研究逐渐深入，越来越多的二维无机纳米材料也应用于光声成像造影剂，尤其是新型类石墨烯二维纳米材料，其优异的近红外吸收率类似于石墨烯，光热转换效率高，生物相容性良好，而且部分材料还具备带隙可调特性以及良好的生物降解性，因此有望成为肿瘤光声成像理想的造影剂。其中，二维过渡金属硫化物、二维过渡金属碳/氮化物以及二维单元素材料已被多次报道应用于肿瘤光声成像造影剂的研发。该文将综述上述几类二维纳米材料在肿瘤光声成像诊断中的应用进展。

通讯作者：刘金文 , Email:jinwenliu@hnu.edu.cn 刘斯佳 , Email:heming_liu@163.com

Research progress of novel graphene-like two-dimensional nanomaterials applied in photoacoustic imaging of tumor

LI Jin-Ling , LU Xin-Liang , FU Ya-Wei , LIU Jin-Wen^* , LIU Si-Jia^*

Guangxi-ASEAN Collaborative Innovation Center for Major Disease Prevention and Treatment, School of Basic Medical Sciences, Guangxi Medical University, Nanning 530021, China

Abstract:

Photoacoustic imaging is an emerging non-invasive biological imaging method with extremely high spatial resolution and good imaging contrast, which is gradually used in basic research for diagnosis of tumor imaging. Photoacoustic imaging mainly depends on photoacoustic signal conversion, and the photoacoustic signal conversion ability mainly depends on the choice of contrast agent. In recent years, as the research of inorganic nanomaterials in the field of biomedical imaging has gradually deepened, more and more two-dimensional inorganic nanomaterials are also used in photoacoustic imaging contrast agents, especially the novel graphene-like twodimensional nanomaterials. Because they have excellent near-infrared absorption rate similar to graphene, high photothermal conversion efficiency, good biocompatibility, and some of them are band-gap adjustable and biodegradable, they are expected to be the ideal contrast agents for tumor photoacoustic imaging. Among them, two-dimensional transition metal sulfides, two-dimensional transition metal carbides and nitrides and twodimensional monoelemental materials have been reported for many times in research and development of contrast agents for tumor photoacoustic imaging. This article will review the advances in the application of these types of nanomaterials in the diagnosis of tumor photoacoustic imaging.

Communication Author：LIU Jin-Wen , Email:jinwenliu@hnu.edu.cn LIU Si-Jia , Email:heming_liu@163.com