《生命科学》 2021, 33(4): 419-417

包含主要协同转运蛋白超家族结构域蛋白2a的研究进展

曾　茹¹ , 贺桂琼^2,*

¹重庆医科大学2016级基础医学专业，重庆 400016 ²重庆医科大学神经科学研究中心 重庆 400016

摘　要：

包含主要协同转运蛋白超家族结构域蛋白2a (major facilitator superfamily domain containing protein 2a, MFSD2A)属于主要协同转运蛋白超家族(major facilitator superfamily, MFS)，其在血脑屏障(blood-brain barrier, BBB)完整性的维持和二十二碳六烯酸(docosahexaenoic acid, DHA)的转运上发挥着重要作用。在敲除 MFSD2A基因的小鼠脑内，DHA含量显著降低并伴有神经元丢失，从而导致小头畸形和认知障碍。基于MFSD2A在中枢神经系统(central nervous system, CNS)的作用，已初步提示MFSD2A在药物输送到CNS方面可能是一个潜在治疗靶蛋白。该文回顾了当前MFSD2A的研究进展，总结梳理了MFSD2A在机体中的正常生理功能，以及在多种疾病(尤其是阿尔茨海默病)发生发展中的作用。

通讯作者：贺桂琼 , Email:guiqionghe@cqmu.edu.cn

Research progress of major facilitator superfamily domain containing protein 2a

ZENG Ru¹ , HE Gui-Qiong^2,*

¹Basic Medical Major of 2016 Batch, Chongqing 400016, China ²Institute of Neuroscience, Chongqing Medical University, Chongqing 400016, China

Abstract:

Major facilitator superfamily domain containing protein 2a (MFSD2A), as a member of the major facilitator superfamily (MFS), plays a crucial part in maintaining the integrity of the blood-brain barrier (BBB) and transporting docosahexaenoic acid (DHA). MFSD2A-deficient (MFSD2A-knockout) mice have shown a marked decrease of DHA levels in brain and neuron loss, which leads to microcephaly and cognitive deficits. Base on the roles of MFSD2A in the central nervous system (CNS), the current researches have preliminarily shown that MFSD2A may be a potential therapeutic target for drug delivery into the CNS. This article reviewed the current research progress of MFSD2A, and summarized its normal physiological functions and role in the occurrence and development of various diseases, especially Alzheimer's disease (AD).

Communication Author：HE Gui-Qiong , Email:guiqionghe@cqmu.edu.cn