《生命科学》 2021, 33(3): 374-382

OXR1基因的抗氧化作用及分子机制研究进展

徐　浩 , 苗晓敏 , 李　升 , 李　云^*

西南大学水产学院，淡水鱼类资源与生殖发育教育部重点实验室，重庆 400715

摘　要：

抗氧化基因1 (oxidation resistance gene 1, OXR1)是一种仅存在于真核生物中，具有清除活性氧、防止细胞氧化损伤的抗氧化调节基因，近年来相关研究甚多。在哺乳动物中，OXR1高表达于中枢神经系统，对神经细胞的抗氧化保护起到至关重要的作用，并发现其功能在人类神经退行性疾病的靶向基因治疗中具有潜在应用价值。该文就OXR1的结构、亚细胞定位、抗氧化功能及表达调控等进行综述，以助于深入理解OXR1对细胞抗氧化保护的分子调控机制。

通讯作者：李　云 , Email:aquatics@swu.edu.cn

New research advances on the functions and molecular mechanisms of oxidation resistance gene 1 

XU Hao , MIAO Xiao-Min , LI Sheng , LI Yun^*

Key Laboratory of Freshwater Fish Reproduction and Development (Ministry of Education), College of Fisheries, Southwest University, Chongqing 400715, China

Abstract:

Oxidation resistance gene 1 (OXR1) is one of the antioxidant regulatory factor that only occurs in eukaryotes and can scavenge reactive oxygen species (ROS) and prevent cell oxidative damage. In recent years, studies have shown that in mammals, OXR1 is highly expressed in central nervous system, which plays a crucial role in the antioxidant defenses of neuron, and it has potential application values in targeted gene therapy for human
neurodegenerative diseases. In this review, the structure, subcellular localization, antioxidant functions and expression regulation of OXR1 were summarized for further understanding the molecular regulatory mechanisms of OXR1 in responding oxidative stress.

 

Communication Author：LI Yun , Email:aquatics@swu.edu.cn