《生命科学》 2021, 33(3): 337-345

SARS-CoV-2入侵细胞相关分子结构与机制的研究进展

李沛霖 , 刘海英^*

中山大学生命科学学院，基因功能与调控教育部重点实验室，广州 510275

摘　要：

新型冠状病毒肺炎(corona virus disease 2019, COVID-19)疫情的迅速发展与其病原体新型冠状病毒(severe acute respiratory syndrome coronavirus 2, SARS-CoV-2)具有的高传播、高感染能力关系密切。这是一种新型β属冠状病毒，为了探究其高传染性的原因，并为治疗药物和防控疫苗的开发提供理论依据，研究人员迅速展开了针对新型冠状病毒入侵细胞分子机制的研究，并取得了较多进展。该文以新型冠状病毒表面的刺突糖蛋白(spike glycoprotein, S protein)和宿主细胞表面的血管紧张素转换酶2 (angiotensin converting enzyme 2, ACE2)的相互作用为重点，介绍了此病毒入侵细胞的分子结构与机制的最新研究进展，总结了病毒入侵环节中潜在的药物靶点，并对新型冠状病毒的研究提出了展望。

 

通讯作者：刘海英 , Email:liuhy5@mail.sysu.edu.cn

Advances in molecular structure and mechanism of SARS-CoV-2 invading cells 

LI Pei-Lin , LIU Hai-Ying^*

MOE Key Laboratory of Gene Function and Regulation, School of Life Sciences,

Abstract:

The rapid spread of pandemic corona virus disease 2019 (COVID-19) is ascribed to the high transmissibility and infectivity of its pathogen severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2). To
better understand the characteristics of this novel β-coronavirus and lay the foundation for COVID-19 prevention and treatment, many researchers focused on the molecular structure and mechanism of SARS-CoV-2 invading into host cells, and have made considerable progress. Here, we systematically reviewed the progressions on the interaction between spike glycoprotein (S protein) of SARS-CoV-2 and angiotensin-converting enzyme 2 (ACE2) of host cells. In this review, we introduced the molecular structures and invasion mechanism of SARS-CoV-2,
summarized the potential drug targets during the virus invasion process, and finally provided a view on the future
development of SARS-CoV-2 research.

 

Communication Author：LIU Hai-Ying , Email:liuhy5@mail.sysu.edu.cn