《生命科学》 2021, 33(2): 231-237

沙门氏菌I型菌毛研究进展

王思权 , 丁雪燕 , 朱国强^*

扬州大学兽医学院，江苏省动物重要疫病与人兽共患病防控协同创新中心， 教育部农业与农产品安全国际合作联合实验室，扬州 225009

摘　要：

据WHO估计，全球每年有数十亿人患食源性疾病，其中由沙门氏菌感染引起的死亡就超过23万人。在沙门氏菌众多的毒力因子中，菌毛在该病原体感染过程中发挥了不可或缺的作用。菌毛(又称纤毛)是细菌表面的丝状蛋白附属物，是细菌对宿主细胞产生作用和造成感染的关键因子。其中，I型菌毛是肠杆菌科成员(包括沙门氏菌)中最常见的菌毛之一，对于细菌启动和发挥致病作用至关重要。鉴于I型菌毛对沙门氏菌的重要性，现就沙门氏菌I型菌毛的结构、表达调控、致病性及其与其他毒力因子的相互作用等方面展开讨论，旨在为靶向I型菌毛来研究沙门氏菌的致病机理提供一定的理论参考。

通讯作者：朱国强 , Email:yzgqzhu@yzu.edu.cn

The research progress of Salmonella type I fimbriae

WANG Si-Quan , DING Xue-Yan , ZHU Guo-Qiang^*

College of Veterinary Medicine, Jiangsu Co-innovation Center for Prevention and Control of Important Animal Infectious Diseases and Zoonoses, Joint International Research Laboratory of Agriculture and Agri-Product Safety, the Ministry of Education of China, Yangzhou University, Yangzhou 225009, China

Abstract:

Based on the data from WHO, billions of people worldwide suffer from foodborne diseases each year, of which 230 000 die from Salmonella infection. Among Salmonella virulent factors, fimbriae play a significant role in Salmonella-related infection. Fimbriae (also known as cilium) are a kind of filamentous protein presenting on bacterial surface, which are responsible for bacteria-host interaction and infection. As one of the most common fimbriae in enterobacteriaceae (including Salmonella), type I fimbriae are crucial to initial attachment and pathogenic infection of bacteria. Considering the importance of Salmonella type I fimbriae, this review mainly focused on the structure, expression regulation, interactions with other virulent factors and pathogenicity of type I fimbriae. The aim of this review is to provide a systematic theoretical reference for targeting type I fimbriae to explore the pathogenic mechanism of Salmonella.

Communication Author：ZHU Guo-Qiang , Email:yzgqzhu@yzu.edu.cn