《生命科学》 2021, 33(2): 223-230

基于蛋白质基因组学发现的新编码序列在疾病中的研究进展

蒙书红^1,2 , 张　瑶^2,* , 徐　平^2,*

¹河北大学生命科学学院，保定 071002 ²军事科学院军事医学研究院生命组学研究所，国家蛋白质科学中心·北京，北京 蛋白质组研究中心，蛋白质组学国家重点实验室，中国医学科学院蛋白质组学与新药研发新技术创新单元，北京 102206

摘　要：

非编码序列在不同物种全基因组中占了很大的比例，在人类基因组中高达98%以上。近年来，越来越多的研究发现，新编码序列不仅参与调控发育、分化、增殖与凋亡等生命活动，而且在疾病的发生发展等过程中也扮演了重要的角色。现对基于蛋白质基因组学发现的新编码序列在疾病中的鉴定及应用进行综述，有望为疾病预测、分型、诊断、治疗、疗效判断及预后的新型生物标志物和潜在治疗靶点研究提供丰富源泉。

通讯作者：张　瑶 , Email:zhangyaowsw@163.com 徐　平 , Email:xupingghy@gmail.com

Progress on novel coding sequences by proteogenomics in diseases research

MENG Shu-Hong^1,2 , ZHANG Yao^2,* , XU Ping^2,*

¹College of Life Sciences, Hebei University, Baoding 071002, China ²Research Unit of Proteomics & Research and Development of New Drug of Chinese Academy of Medical Sciences, State Key Laboratory of Proteomics, Beijing Proteome Research Center, National Center for Protein Sciences.Beijing, Institute of Lifeomics, Academy of Military Medical Sciences, Academy of Military Sciences, Beijing 102206, China

Abstract:

Non-coding sequences account for a large proportion in whole genome of different species, especially in human genome which is up to 98%. In recent years, an increasing number of studies have shown that novel coding sequences not only participate in life activities, such as the regulation of development, differentiation, proliferation, and apoptosis, and so on, but also play a significant role in occurrence and development of diseases. This paper reviewed the discovery and application of novel coding sequences based on proteogenomics in various diseases, which will provide rich resources for researching novel biomarkers and potential therapeutic targets of disease prediction, classification, diagnosis, treatment, curative effect judgment and prognosis.

Communication Author：ZHANG Yao , Email:zhangyaowsw@163.com XU Ping , Email:xupingghy@gmail.com