《生命科学》 2021, 33(2): 184-191

剪接因子PTBP1生物学功能研究进展

张　倩^1,2 , 曹鹏博² , 金　倩² , 周钢桥^1,2,*

¹贵州大学医学院，贵阳 520025 ²军事科学院军事医学研究院辐射医学研究所， 蛋白质组学国家重点实验室，国家蛋白质中心(北京)，北京 100850

摘　要：

多聚嘧啶区结合蛋白1 (polypyrimidine tract-binding protein 1, PTBP1)是一种常见的RNA结合蛋白，在多种疾病的发生和发展中发挥重要作用。PTBP1的一个主要功能是作为剪接因子(splicing factor, SF)。它通过结合靶基因前体mRNA的特定序列，选择性地剪接外显子或内含子从而产生不同的mRNA亚型，进而在细胞分化、细胞周期与凋亡、细胞运动、细胞代谢和免疫响应等多个生物学过程中发挥重要的调控作用。

通讯作者：周钢桥 , Email:zhougq114@126.com

Advances in research on the biological functions of splicing factor PTBP1

ZHANG Qian^1,2 , CAO Peng-Bo² , JIN Qian² , ZHOU Gang-Qiao^1,2,*

¹Medical College at Guizhou University, Guiyang 550025, China ²State Key Lab of Proteomics, National Center for Protein Sciences at Beijing, Institute of Radiation Medicine, Academy of Military Medical Sciences, Academy of Military Sciences, Beijing 100850, China

Abstract:

Polypyrimidine tract binding protein 1 (PTBP1) is a common RNA binding protein that plays an essential role in the occurrence and development of various diseases. The main function of PTBP1 is acting as a splicing factor (SF). It can bind to the specific sequence of target pre-mRNAs, and direct alternative splicing to produce multiple mRNA isoforms, thus participating in many cellular biological processes such as cell differentiation, cell cycle transition and apoptosis, cell motility, cell metabolism and immune response.

Communication Author：ZHOU Gang-Qiao , Email:zhougq114@126.com