《生命科学》 2021, 33(2): 176-183

B淋巴酪氨酸激酶的研究进展

倪佳俐¹ , 侯亚义² , 窦　环^2,*

¹南京大学生命科学学院，南京 210023 ²南京大学医学院，南京 210023

摘　要：

B淋巴酪氨酸激酶(BLK)是SRC激酶家族成员之一，具有酪氨酸蛋白激酶活性。BLK作为“中间分子”参与免疫细胞发育、迁移和增殖等生理过程中的信号转导；在疾病进程中，BLK通常表现为表达量降低或激酶活性下降。因此，对BLK的研究将有助于探索发病机制，这对指导临床诊断和治疗具有重要意义。现对BLK的分子特点、功能及其在疾病中的作用进行综述。

通讯作者：窦　环 , Email:douhuan@nju.edu.cn

Research progress on the B lymphoid tyrosine kinase

NI Jia-Li¹ , HOU Ya-Yi² , DOU Huan^2,*

¹School of Life Sciences, Nanjing University, Nanjing 210023, China ²Medical School of Nanjing University, Nanjing 210023, China

Abstract:

B lymphoid tyrosine kinase (BLK) is one of the SRC kinase family members, which exhibits tyrosine protein kinase activity. As an “intermediate molecule”, BLK is involved in signaling transduction of physiological processes such as cell development, cell migration and proliferation. BLK generally manifests as decreased expression or diminished activity in the course of disease progression. Research on BLK has significant implications for the study of molecular mechanisms of disease and clinical treatment. Our review highlighted the molecular characteristics, functions and its roles in diseases.

Communication Author：DOU Huan , Email:douhuan@nju.edu.cn