《生命科学》 2021, 33(2): 154-165

线粒体结构和功能改变对阿尔茨海默病发生的影响

安超群¹ , 杨友涵¹ , 魏　珍^1,2 , 曾　燕^1,*

¹武汉科技大学脑科学先进技术研究院，武汉 430065 ²武汉科技大学职业危害识别与控制湖北省重点实验室，武汉 430065

摘　要：

阿尔茨海默病(Alzheimer’s disease, AD)是一种以进行性认知障碍和行为损害为主要特征的神经退行性疾病，主要临床表现为认知功能障碍，同时伴发精神障碍和情绪障碍。AD患者脑中早期即表现出细胞内线粒体功能紊乱和结构变化，纠正线粒体稳态失衡及由其引起的细胞病理改变可能是早期治疗AD的潜在靶点。该文主要对线粒体膜、线粒体相关内质网膜和线粒体呼吸链的结构与功能改变在AD病理进程中的意义和生物学影响进行综述。

通讯作者：曾　燕 , Email:yanzeng11@foxmail.com

Effects of abnormal mitochondrial structure and function on the occurrence of Alzheimer's disease

AN Chao-Qun¹ , YANG You-Han¹ , WEI Zhen^1,2 , ZENG Yan^1,*

¹Brain Science and Advanced Technology Institute, Wuhan University of Science and Technology, Wuhan 430065, China ²Hubei Province Key Laboratory of Occupational Hazard Identification and Control, Wuhan University of Science and Technology, Wuhan 430065, China

Abstract:

Alzheimer's disease (AD) is a neurodegenerative disease characterized by progressive cognitive impairment and behavioral impairment. The main clinical manifestations of AD are cognitive dysfunction, accompanied by mental and emotional disorders. In this review, we will systematically summarize the biological effects of structural and functional changes of mitochondria, including mitochondrial membranes, mitochondria associated endoplasmic reticulum membranes and mitochondrial respiratory chain, on the pathological process of AD, and highlight the potential therapeutic applications for early treatment of AD.

Communication Author：ZENG Yan , Email:yanzeng11@foxmail.com