《生命科学》 2021, 33(2): 148-153

非洲爪蛙：一种研究肾脏发育和多囊肾的优势动物模型

张　茜¹ , 张　博^2,*

¹天津市河西区妇女儿童保健和计划生育服务中心检验科，天津 300202 ²天津医科大学基础医学院免疫学系，天津 300070

摘　要：

非洲爪蛙(Xenopus laevis)是目前基础研究中广泛使用的重要动物模型，主要用于研究脊椎动物各组织器官的早期发育。相对于其他动物模型，非洲爪蛙在肾脏发育和多囊肾相关疾病探索中的优势更为显著。非洲爪蛙肾脏简单，但进化保守，实验技术简便，但结果可靠，对于肾脏发育和疾病发展中的复杂基因调控网络研究非常重要。虽然小鼠和大鼠的后肾目前是研究肾脏的主要模型，但非洲爪蛙对于多发性肾脏疾病研究仍然不可或缺。该文就非洲爪蛙的肾脏发育特点和作为模型动物研究多囊肾疾病的优缺点做一综述。

通讯作者：张　博 , Email:zhangbomianyi@163.com

Xenopus laevis: a dominant animal model for studying kidney development and polycystic kidney disease

ZHANG Qian¹ , ZHANG Bo^2,*

¹Department of Laboratory, Women and Children’s Health and Family Planning Service Center of Hexi District, Tianjin 300202, China ²Department of Immunology, School of Basic Medical Sciences, Tianjin Medical University, Tianjin 300070, China

Abstract:

The African clawed frog (Xenopus laevis) is an important animal model widely used in basic research. It is mainly developed to study the early development of various vertebrate tissues and organs. Compared with other animal models, it is related to kidney development and polycystic kidney disease. The advantages are very obvious in disease exploration. The Xenopus laevis kidney is simple but evolutionarily conservative, and the experimental technology is simple but the results are reliable. It is the key for the study of complex gene regulatory networks in kidney development and disease development. Although the metanephrosis of mice and rats is currently used, the characteristics of the Xenopus laevis itself are indispensable for the study of multiple kidney diseases. This article focuses on the characteristics of the kidney development of the Xenopus laevis and its advantages as a model animal to study polycystic kidney disease. The shortcomings are also reviewed.

Communication Author：ZHANG Bo , Email:zhangbomianyi@163.com