《生命科学》 2021, 33(2): 139-147

浮舰蛋白flotillins在细胞生理和疾病中的作用

骆瑜豪 , 纪雯宇 , 李春条 , 徐源聪 , 沈万华^*

杭州师范大学浙江省器官发育与再生技术研究重点实验室，杭州 311121

摘　要：

浮舰蛋白flotillin-1和flotillin-2参与多个细胞生理活动过程，包括调节细胞黏附、物质内吞、蛋白质分选与再循环和细胞迁移，同时也与一些退行性疾病和肿瘤的发生发展有密切联系。该文介绍了flotillins的结构与定位，综述了flotillins从发现至今影响个体形态发生、神经元生长和功能以及调控多个信号转导途径等几个方面的研究进展，并展望flotillins在疾病机制研究以及临床诊断治疗中的作用。

通讯作者：沈万华 , Email:shen@hznu.edu.cn

The effects of flotillins on cellular physiology and diseases

LUO Yu-Hao , JI Wen-Yu , LI Chun-Tiao , XU Yuan-Cong , SHEN Wan-Hua^*

Zhejiang Key Laboratory of Organ Development and Regeneration, Hangzhou Normal University, Hangzhou 311121, China

Abstract:

Flotillin-1 and flotillin-2 are involved in many cellular physiological processes, including regulation of cell adhesion, cargo endocytosis, protein sorting and recycling, and cell migration. Flotillins are also closely related to the occurrence and development of some degenerative diseases and tumors. In this review, we first introduced the structure and distribution of flotillins. Then, we summarized the recent progress of flotillins since its discovery, including the impact on morphogenesis, neural growth and function, as well as the regulation of multiple signal transduction pathways. Finally, the role of flotillins in the research of disease mechanism and clinical diagnosis and treatment was prospected.

Communication Author：SHEN Wan-Hua , Email:shen@hznu.edu.cn