《生命科学》 2005, 17(3):

整合蛋白信号转导研究进展

田 芳，缪泽鸿，章雄文，丁 健^*

中国科学院上海生命科学研究院上海药物研究所，新药研究国家重点实验室，中国科学院研究生院，上海 201203

摘　要：
摘　要：细胞外基质受体整合蛋白全方位影响细胞的形态、运动、存活和增殖。它通过介导复杂的信号通路，将细胞外信息内传，调控细胞的生命活动。本文综述了整合蛋白的活化过程、信号转导过程及其与生长因子受体信号通路相互关联研究的最新进展。
关键词：细胞外基质；整合蛋白活化；整合蛋白信号

Advance in integrin activation and signaling

TIAN Fang, MIAO Ze-Hong, ZHANG Xiong-Wen, DING Jian^*

Shanghai Institute of Materia Medica, Shanghai Institutes for Biological Sciences, Chinese Academy of Sciences, Graduate School of CAS, Shanghai 201203, China

Abstract: Abstract: Integrins, a large family of receptors that attach cells to the matrix, exert an extraordinary control on cell adhesion, migration, proliferation and survival. Integrins recognize cues encoded by the extra-cellular matrix and convert them into complex biochemical signals that control the behavior of cells. In this paper, we review the recent research concerning the integrin activation and integrin signaling, as well as their cooperation with receptor protein tyrosine kinases.
Key words: extra-cellular matrix; integrin activation; integrin signaling